ERK2
MAPK1
PRKM1
PRKM2
UniProt:P28482 MAPK1
Adenylate cyclase produces cAMP
cAMP induces dissociation of inactive PKA tetramers
PKA catalytic subunit translocates to the nucleus
PKA phosphorylates CREB
Dimerisation of CREB
Calmodulin binds CaMK IV
CamKIV enters the nucleus
CaMK IV autophosphorylation
CaMK IV phosphorylates CREB
Calmodulin activates Cam-PDE 1
cAMP hydrolysis by Cam-PDE 1
Inhibition of GRK2 by calmodulin
PKC phosphorylates GRK2
Calcium binds calmodulin
G alpha (i) inhibits adenylate cyclase
G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex
Adenylate cyclase increases the GTPase activity of G alpha-olf
Adenylate cyclase increases the GTPase activity of Gi alpha
Dissociation of the Gi alpha:G olf complex
Activation of PLC beta-1/4
PIP2 hydrolysis
Inactivation of PLC beta
Phosphorylation of cPLA2 by ERK-2
Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase
Hydrolysis of phosphatidylcholine
Galpha-olf:GTP binds to adenylate cyclase and activates it
Adenylate cyclase converts ATP into cyclic AMP
Adenylaye cyclase increases the GTPase activity of G alpha-olf
The G alpha-olf:GDP:Adenylate cyclase complex dissociates
IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel
Release of calcium from intracellular stores by IP3 receptor activation
G-protein mediated events
PLC beta mediated events
Ca-dependent events
phospho-PLA2 pathway
Adenylate cyclase activating pathway
CaM pathway
Calmodulin induced events
PKA-mediated phosphorylation of CREB
PKA activation
CaMK IV-mediated phosphorylation of CREB
Cam-PDE 1 activation
Adenylate cyclase inhibitory pathway