Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate
Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz
Liganded Gz-activating GPCR acts as a GEF for Gz
The Ligand:GPCR:Gz complex dissociates
G alpha (z) inhibits adenylate cyclase
Gz is a substrate for PKC
G alpha (z) auto-inactivates by hydrolysing GTP to GDP
Inactive G alpha (z) reassociates with G beta:gamma
G alpha (z) signalling events