Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004016
BFO_0000050: G alpha (z) signalling events
directly activates: BiochemicalReaction4345
directly activates: Catalysis1879

Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz
type: GO_0003674
BFO_0000050: G alpha (z) signalling events
directly activates: Liganded Gz-activating GPCR acts as a GEF for Gz
directly activates: Catalysis1884

Liganded Gz-activating GPCR acts as a GEF for Gz
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005085
BFO_0000050: G alpha (z) signalling events
directly activates: The Ligand:GPCR:Gz complex dissociates

The Ligand:GPCR:Gz complex dissociates
type: GO_0003674
BFO_0000050: G alpha (z) signalling events
directly activates: G alpha (z) inhibits adenylate cyclase
directly activates: G alpha (z) auto-inactivates by hydrolysing GTP to GDP
directly activates: Catalysis1886
directly activates: Control344

G alpha (z) inhibits adenylate cyclase
type: GO_0003674
BFO_0000050: G alpha (z) signalling events
directly activates: Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate
directly activates: Catalysis1878
directly activates: Control340
directly activates: Control341
directly activates: Control342

Gz is a substrate for PKC
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004697
BFO_0000050: G alpha (z) signalling events

G alpha (z) auto-inactivates by hydrolysing GTP to GDP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0003924
BFO_0000050: G alpha (z) signalling events
directly activates: Inactive G alpha (z) reassociates with G beta:gamma

Inactive G alpha (z) reassociates with G beta:gamma
type: GO_0003674
BFO_0000050: G alpha (z) signalling events

G alpha (z) signalling events
type: GO_0008150