MGLL
UniProt:Q99685 MGLL
Transport of Ca++ from platelet dense tubular system to cytoplasm
Binding of IP3 to IP3 receptor
Calcium and Diacylglycerol activate CalDAG-GEFs (RasGRPs)
Activation of Protein Kinase C novel isoforms
DAG activation of TRPC channels
DAG is metabolized by DAGL to 2-AG
2-AG hydrolysis to arachidonate by MAGL
DAG kinase produces phosphatidic acid from DAG
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
The Ligand:GPCR:Gq complex dissociates
GRK2 sequesters activated Gq
GRK5 sequesters activated Gq
G alpha (q) binds to Trio family RhoGEFs
PLC beta is activated by G alpha (q)
G alpha (q) inhibits PI3K alpha
PLC beta-mediated PIP2 hydrolysis
G alpha (q) auto-inactivates by hydrolysing GTP to GDP
Inactive G alpha (q) reassociates with G beta:gamma
G alpha (q) signalling events
Effects of PIP2 hydrolysis
Arachidonate production from DAG