MGLL
label: UniProt:Q99685 MGLL

Transport of Ca++ from platelet dense tubular system to cytoplasm
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031095
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031095
type: GO_0005262
BFO_0000050: Effects of PIP2 hydrolysis
directly activates: Calcium and Diacylglycerol activate CalDAG-GEFs (RasGRPs)
directly activates: BiochemicalReaction2356
directly activates: BiochemicalReaction242
directly activates: Control159

Binding of IP3 to IP3 receptor
type: GO_0003674
BFO_0000050: Effects of PIP2 hydrolysis
directly activates: Transport of Ca++ from platelet dense tubular system to cytoplasm
directly activates: Catalysis1004

Calcium and Diacylglycerol activate CalDAG-GEFs (RasGRPs)
type: GO_0003674
BFO_0000050: Effects of PIP2 hydrolysis
directly activates: BiochemicalReaction850
directly activates: BiochemicalReaction851
directly activates: Catalysis321
directly activates: Catalysis322

Activation of Protein Kinase C novel isoforms
type: GO_0003674
BFO_0000050: Effects of PIP2 hydrolysis

DAG activation of TRPC channels
type: GO_0003674
BFO_0000050: Effects of PIP2 hydrolysis
directly activates: BiochemicalReaction2250
directly activates: Catalysis1006

DAG is metabolized by DAGL to 2-AG
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0047372
BFO_0000050: Arachidonate production from DAG
directly activates: 2-AG hydrolysis to arachidonate by MAGL
directly activates: Catalysis1037

2-AG hydrolysis to arachidonate by MAGL
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: enabled by
  some values from: MGLL
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0047372
BFO_0000050: Arachidonate production from DAG

DAG kinase produces phosphatidic acid from DAG
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004143
BFO_0000050: Effects of PIP2 hydrolysis

Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
type: GO_0003674
BFO_0000050: G alpha (q) signalling events
directly activates: Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
directly activates: Catalysis1887

Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005085
BFO_0000050: G alpha (q) signalling events
directly activates: The Ligand:GPCR:Gq complex dissociates
directly activates: BiochemicalReaction4384
directly activates: BiochemicalReaction4386

The Ligand:GPCR:Gq complex dissociates
type: GO_0003674
BFO_0000050: G alpha (q) signalling events
directly activates: GRK2 sequesters activated Gq
directly activates: GRK5 sequesters activated Gq
directly activates: G alpha (q) binds to Trio family RhoGEFs
directly activates: PLC beta is activated by G alpha (q)
directly activates: G alpha (q) inhibits PI3K alpha
directly activates: G alpha (q) auto-inactivates by hydrolysing GTP to GDP
directly activates: Catalysis1889
directly activates: Control345

GRK2 sequesters activated Gq
type: GO_0003674
BFO_0000050: G alpha (q) signalling events

GRK5 sequesters activated Gq
type: GO_0003674
BFO_0000050: G alpha (q) signalling events

G alpha (q) binds to Trio family RhoGEFs
type: GO_0003674
BFO_0000050: G alpha (q) signalling events

PLC beta is activated by G alpha (q)
type: GO_0003674
BFO_0000050: G alpha (q) signalling events
directly activates: PLC beta-mediated PIP2 hydrolysis
directly activates: Catalysis1888

G alpha (q) inhibits PI3K alpha
type: GO_0003674
BFO_0000050: G alpha (q) signalling events

PLC beta-mediated PIP2 hydrolysis
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004629
BFO_0000050: G alpha (q) signalling events
directly activates: Binding of IP3 to IP3 receptor
directly activates: Calcium and Diacylglycerol activate CalDAG-GEFs (RasGRPs)
directly activates: Activation of Protein Kinase C novel isoforms
directly activates: DAG activation of TRPC channels
directly activates: DAG is metabolized by DAGL to 2-AG
directly activates: DAG kinase produces phosphatidic acid from DAG
directly activates: BiochemicalReaction2356
directly activates: BiochemicalReaction4418
directly activates: BiochemicalReaction715
directly activates: Catalysis1036
directly activates: Catalysis1038
directly activates: Control159

G alpha (q) auto-inactivates by hydrolysing GTP to GDP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0003924
BFO_0000050: G alpha (q) signalling events
directly activates: Inactive G alpha (q) reassociates with G beta:gamma

Inactive G alpha (q) reassociates with G beta:gamma
type: GO_0003674
BFO_0000050: G alpha (q) signalling events

G alpha (q) signalling events
type: GO_0008150

Effects of PIP2 hydrolysis
type: GO_0008150
BFO_0000050: G alpha (q) signalling events

Arachidonate production from DAG
type: GO_0008150
BFO_0000050: Effects of PIP2 hydrolysis