CHEK1
CHK1
UniProt:O14757 CHEK1
CDS1
CHEK2
CHK2
RAD53
UniProt:O96017-12 CHEK2
ATM
UniProt:Q13315 ATM
COP1
RFWD2
RNF200
UniProt:Q8NHY2 RFWD2
Phosphorylation of p53 at ser-15 by ATM kinase
Phosphorylation of MDM2 at serine-395 by ATM kinase
Phosphorylation of COP1 at Ser-387 by ATM
Dissociation of the COP1-p53 complex
Translocation of COP1 from the nucleus to the cytoplasm
Autoubiquitination of phospho-COP1(Ser-387 )
Proteasome mediated degradation of COP1
Inactivation of Cyclin E:Cdk2 complexes by p27/p21
Phosphorylation of Cdc25A at Ser-123 in response to DNA damage
Phosphorylation of Cdc25A at Ser-123 by Chk2
Ubiquitination of phosphorylated Cdc25A
Proteolytic degradation of ubiquitinated-Cdc25A
Phosphorylation and activation of Chk1 by ATM
Phosphorylation of Cdc25A at Ser-123 by Chk1
G1/S DNA Damage Checkpoints
p53-Dependent G1/S DNA damage checkpoint
p53-Dependent G1 DNA Damage Response
Stabilization of p53
Autodegradation of the E3 ubiquitin ligase COP1
Transcriptional activation of p53 responsive genes
Transcriptional activation of cell cycle inhibitor p21
p53-Independent G1/S DNA damage checkpoint
p53-Independent DNA Damage Response
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Transcriptional activation of p21 by p53 after DNA damage