CHEK1
label: CHK1
label: UniProt:O14757 CHEK1

CDS1
label: CHEK2
label: CHK2
label: RAD53
label: UniProt:O96017-12 CHEK2

ATM
label: UniProt:Q13315 ATM

COP1
label: RFWD2
label: RNF200
label: UniProt:Q8NHY2 RFWD2

Phosphorylation of p53 at ser-15 by ATM kinase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Stabilization of p53
directly activates: TemplateReaction149
directly activates: TemplateReaction151
directly activates: TemplateReactionRegulation173
directly activates: TemplateReactionRegulation175

Phosphorylation of MDM2 at serine-395 by ATM kinase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Stabilization of p53

Phosphorylation of COP1 at Ser-387 by ATM
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Autodegradation of the E3 ubiquitin ligase COP1
directly activates: Dissociation of the COP1-p53 complex
directly activates: Translocation of COP1 from the nucleus to the cytoplasm

Dissociation of the COP1-p53 complex
type: GO_0003674
BFO_0000050: Autodegradation of the E3 ubiquitin ligase COP1

Translocation of COP1 from the nucleus to the cytoplasm
type: GO_0003674
BFO_0000050: Autodegradation of the E3 ubiquitin ligase COP1
directly activates: Autoubiquitination of phospho-COP1(Ser-387 )
directly activates: Catalysis806

Autoubiquitination of phospho-COP1(Ser-387 )
type: Restriction
  on property: enabled by
  some values from: COP1
type: Restriction
  on property: enabled by
  some values from: COP1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: COP1
type: Restriction
  on property: enabled by
  some values from: COP1
type: Restriction
  on property: enabled by
  some values from: COP1
type: Restriction
  on property: enabled by
  some values from: COP1
type: Restriction
  on property: enabled by
  some values from: COP1
type: Restriction
  on property: enabled by
  some values from: COP1
type: Restriction
  on property: enabled by
  some values from: COP1
type: Restriction
  on property: enabled by
  some values from: COP1
type: Restriction
  on property: enabled by
  some values from: COP1
type: Restriction
  on property: enabled by
  some values from: COP1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: COP1
type: Restriction
  on property: enabled by
  some values from: COP1
type: Restriction
  on property: enabled by
  some values from: COP1
type: Restriction
  on property: enabled by
  some values from: COP1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004842
BFO_0000050: Autodegradation of the E3 ubiquitin ligase COP1
directly activates: Proteasome mediated degradation of COP1
directly activates: Catalysis807

Proteasome mediated degradation of COP1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004175
BFO_0000050: Autodegradation of the E3 ubiquitin ligase COP1

Inactivation of Cyclin E:Cdk2 complexes by p27/p21
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004861
BFO_0000050: p53-Dependent G1 DNA Damage Response
directly activates: BiochemicalReaction1894
directly activates: Catalysis831

Phosphorylation of Cdc25A at Ser-123 in response to DNA damage
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: p53-Independent DNA Damage Response

Phosphorylation of Cdc25A at Ser-123 by Chk2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: CDS1
type: Restriction
  on property: enabled by
  some values from: CDS1
type: Restriction
  on property: enabled by
  some values from: CDS1
type: Restriction
  on property: enabled by
  some values from: CDS1
type: Restriction
  on property: enabled by
  some values from: CDS1
type: Restriction
  on property: enabled by
  some values from: CDS1
type: Restriction
  on property: enabled by
  some values from: CDS1
type: Restriction
  on property: enabled by
  some values from: CDS1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Ubiquitin Mediated Degradation of Phosphorylated Cdc25A

Ubiquitination of phosphorylated Cdc25A
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004842
BFO_0000050: Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
directly activates: Proteolytic degradation of ubiquitinated-Cdc25A
directly activates: Catalysis812

Proteolytic degradation of ubiquitinated-Cdc25A
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004175
BFO_0000050: Ubiquitin Mediated Degradation of Phosphorylated Cdc25A

Phosphorylation and activation of Chk1 by ATM
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
directly activates: Phosphorylation of Cdc25A at Ser-123 by Chk1
directly activates: BiochemicalReaction1852
directly activates: BiochemicalReaction1861
directly activates: Catalysis814
directly activates: Catalysis818
directly activates: Catalysis822

Phosphorylation of Cdc25A at Ser-123 by Chk1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: CHEK1
type: Restriction
  on property: enabled by
  some values from: CHEK1
type: Restriction
  on property: enabled by
  some values from: CHEK1
type: Restriction
  on property: enabled by
  some values from: CHEK1
type: Restriction
  on property: enabled by
  some values from: CHEK1
type: Restriction
  on property: enabled by
  some values from: CHEK1
type: Restriction
  on property: enabled by
  some values from: CHEK1
type: Restriction
  on property: enabled by
  some values from: CHEK1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Ubiquitin Mediated Degradation of Phosphorylated Cdc25A

G1/S DNA Damage Checkpoints
type: GO_0008150

p53-Dependent G1/S DNA damage checkpoint
type: GO_0008150
BFO_0000050: G1/S DNA Damage Checkpoints

p53-Dependent G1 DNA Damage Response
type: GO_0008150
BFO_0000050: p53-Dependent G1/S DNA damage checkpoint

Stabilization of p53
type: GO_0008150
BFO_0000050: p53-Dependent G1 DNA Damage Response

Autodegradation of the E3 ubiquitin ligase COP1
type: GO_0008150
BFO_0000050: Stabilization of p53

Transcriptional activation of p53 responsive genes
type: GO_0008150
BFO_0000050: p53-Dependent G1 DNA Damage Response

Transcriptional activation of cell cycle inhibitor p21
type: GO_0008150
BFO_0000050: Transcriptional activation of p53 responsive genes

p53-Independent G1/S DNA damage checkpoint
type: GO_0008150
BFO_0000050: G1/S DNA Damage Checkpoints

p53-Independent DNA Damage Response
type: GO_0008150
BFO_0000050: p53-Independent G1/S DNA damage checkpoint

Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
type: GO_0008150
BFO_0000050: p53-Independent DNA Damage Response

Transcriptional activation of p21 by p53 after DNA damage
type: GO_0003674
BFO_0000050: Transcriptional activation of cell cycle inhibitor p21