MMP3
label: STMY1
label: UniProt:P08254 MMP3

Activation of Protein kinase C, alpha type by Diacylglycerol
type: GO_0003674
BFO_0000050: EGFR Transactivation by Gastrin
directly activates: BiochemicalReaction5334
directly activates: Catalysis2568
directly activates: Activated PKC-alpha can activate MMP3

Active MMP3 can cleave pro-HBEGF to form active HBEGF
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: enabled by
  some values from: MMP3
type: GO_0004222
BFO_0000050: EGFR Transactivation by Gastrin
directly activates: Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor

Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor
type: GO_0003674
BFO_0000050: EGFR Transactivation by Gastrin
directly activates: GRB2:SOS1 binds to HBEGF:p-Y-EGFR

GRB2:SOS1 binds to HBEGF:p-Y-EGFR
type: GO_0003674
BFO_0000050: EGFR Transactivation by Gastrin
directly activates: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)
directly activates: Catalysis1914

SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005088
BFO_0000050: EGFR Transactivation by Gastrin

EGFR Transactivation by Gastrin
type: GO_0008150

Activated PKC-alpha can activate MMP3
type: GO_0003674
BFO_0000050: EGFR Transactivation by Gastrin
directly activates: Active MMP3 can cleave pro-HBEGF to form active HBEGF
directly activates: Catalysis1913