MMP3
STMY1
UniProt:P08254 MMP3
Activation of Protein kinase C, alpha type by Diacylglycerol
Active MMP3 can cleave pro-HBEGF to form active HBEGF
Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor
GRB2:SOS1 binds to HBEGF:p-Y-EGFR
SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)
EGFR Transactivation by Gastrin
Activated PKC-alpha can activate MMP3