Ficolin-1 binds to molecular patterns on the target cell surface
Ficolin-2 binds to molecular patterns on the target cell surface
Ficolin-3 binds to molecular patterns on the target cell surface
MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa
Activation of MASPs
Activation of C1R
Activation of C1S
Conversion of C4 into C4a and C4b
C4b binds to cell surface
Conversion of C2 into C2a and C2b
Formation of Classical C3 convertase (C4b:C2a complex)
Spontaneous hydrolysis of C3 thioester
Factor B binds to C3(H2O)
Factor D cleaves C3(H2O)-bound Factor B
C3(H2O):Factor Bb cleaves C3 to C3b and C3a
C3b binds to cell surface
Factor B binds to surface-associated C3b
Factor D cleaves C3b-bound Factor B
Properdin stabilizes C3b:Bb bound to cell surfaces
Formation of alternative pathway C5 convertase
Formation of C5b:C6 complex
Formation of C5b:C6:C7 complex
C7 allows complex to insert into membrane under attack
Formation of C5b:C6:C7:C8 complex
Creation of the Membrane Attack Complex (MAC)
Cleavage of C3 by C3 convertases
Formation of classic pathway C5 convertase
Activation of C5
C3 convertases spontaneously dissociate
Factor H binds to C3b
Factor H binds host cell surface markers
Factor H binds to membrane-associated C3b
Factor H binds to C3bBb
Factor H displaces Bb
Complement factor I complex formation
Complement factor I binds to extracellular Factor H:C3b
Factor I inactivates plasma Factor H-bound C3b
Complement factor I binds to membrane-associated Factor H:C3b
Factor I inactivates Factor H-boundC3b
iC3b proteolysis
CR1 binds C3bBb/C4bC2a
Displacement of C2a/Bb by CR1
MCP binds C3b, C4b
Complement factor I binds to MCP, CR1:C4b, C3b
Factor I inactivates MCP/CR1-bound C4b/C3b
DAF binds C3bBb, C4bC2a
DAF accelerates C3bBb/C4bC2a dissociation
C4b-binding protein binds C4b
Complement factor I binds C4BP
Complement factor I inactivates C4BP-bound C4b
C4b binding protein binds C4bC2a
C4b binding protein displaces C2a
C4b binding protein binds Protein S
CD59 inhibits MAC formation
Formation of soluble VTN:C5b-C9
Vitronectin(VTN) binds to C5b:C6:C7
Hydrolysis of internal thioester in C4b
Complement cascade
Initial triggering of complement
Creation of C4 and C2 activators
Lectin pathway of complement activation
Ficolins bind to repetitive carbohydrate structures on the target cell surface
Classical antibody-mediated complement activation
Alternative complement activation
Terminal pathway of complement
Activation of C3 and C5
Regulation of Complement cascade