Ficolin-1 binds to molecular patterns on the target cell surface
type: GO_0003674
BFO_0000050: Ficolins bind to repetitive carbohydrate structures on the target cell surface
directly activates: Activation of MASPs

Ficolin-2 binds to molecular patterns on the target cell surface
type: GO_0003674
BFO_0000050: Ficolins bind to repetitive carbohydrate structures on the target cell surface
directly activates: Activation of MASPs

Ficolin-3 binds to molecular patterns on the target cell surface
type: GO_0003674
BFO_0000050: Ficolins bind to repetitive carbohydrate structures on the target cell surface
directly activates: Activation of MASPs

MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa
type: GO_0003674
BFO_0000050: Lectin pathway of complement activation
directly activates: Activation of MASPs

Activation of MASPs
type: GO_0003674
BFO_0000050: Lectin pathway of complement activation
directly activates: Conversion of C4 into C4a and C4b
directly activates: Conversion of C2 into C2a and C2b
directly activates: Catalysis383
directly activates: Catalysis384

Activation of C1R
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004252
BFO_0000050: Classical antibody-mediated complement activation
directly activates: Activation of C1S
directly activates: Catalysis382

Activation of C1S
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004252
BFO_0000050: Classical antibody-mediated complement activation
directly activates: Conversion of C4 into C4a and C4b
directly activates: Catalysis383

Conversion of C4 into C4a and C4b
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004252
BFO_0000050: Initial triggering of complement
directly activates: C4b binds to cell surface
directly activates: Hydrolysis of internal thioester in C4b

C4b binds to cell surface
type: GO_0003674
BFO_0000050: Initial triggering of complement
directly activates: Formation of Classical C3 convertase (C4b:C2a complex)

Conversion of C2 into C2a and C2b
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004252
BFO_0000050: Initial triggering of complement
directly activates: Formation of Classical C3 convertase (C4b:C2a complex)

Formation of Classical C3 convertase (C4b:C2a complex)
type: GO_0003674
BFO_0000050: Initial triggering of complement
directly activates: Cleavage of C3 by C3 convertases
directly activates: C3 convertases spontaneously dissociate
directly activates: CR1 binds C3bBb/C4bC2a
directly activates: DAF binds C3bBb, C4bC2a
directly activates: Catalysis389

Spontaneous hydrolysis of C3 thioester
type: GO_0003674
BFO_0000050: Alternative complement activation
directly activates: Factor B binds to C3(H2O)

Factor B binds to C3(H2O)
type: GO_0003674
BFO_0000050: Alternative complement activation
directly activates: Factor D cleaves C3(H2O)-bound Factor B
directly activates: Catalysis385

Factor D cleaves C3(H2O)-bound Factor B
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Alternative complement activation
directly activates: C3(H2O):Factor Bb cleaves C3 to C3b and C3a
directly activates: Factor H binds to C3bBb
directly activates: CR1 binds C3bBb/C4bC2a
directly activates: DAF binds C3bBb, C4bC2a
directly activates: Catalysis386
directly activates: Control77

C3(H2O):Factor Bb cleaves C3 to C3b and C3a
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Alternative complement activation
directly activates: C3b binds to cell surface

C3b binds to cell surface
type: GO_0003674
BFO_0000050: Alternative complement activation
directly activates: Factor B binds to surface-associated C3b
directly activates: Factor H binds to membrane-associated C3b
directly activates: Control76

Factor B binds to surface-associated C3b
type: GO_0003674
BFO_0000050: Alternative complement activation
directly activates: Factor D cleaves C3b-bound Factor B
directly activates: Catalysis387

Factor D cleaves C3b-bound Factor B
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Alternative complement activation
directly activates: Properdin stabilizes C3b:Bb bound to cell surfaces
directly activates: Factor H binds to C3bBb
directly activates: CR1 binds C3bBb/C4bC2a
directly activates: DAF binds C3bBb, C4bC2a
directly activates: Control77

Properdin stabilizes C3b:Bb bound to cell surfaces
type: GO_0003674
BFO_0000050: Alternative complement activation
directly activates: Formation of alternative pathway C5 convertase
directly activates: Cleavage of C3 by C3 convertases
directly activates: C3 convertases spontaneously dissociate
directly activates: Catalysis388
directly activates: Catalysis389

Formation of alternative pathway C5 convertase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004252
BFO_0000050: Alternative complement activation
directly activates: Cleavage of C3 by C3 convertases
directly activates: Activation of C5
directly activates: C3 convertases spontaneously dissociate
directly activates: Catalysis389
directly activates: Catalysis390

Formation of C5b:C6 complex
type: GO_0003674
BFO_0000050: Terminal pathway of complement
directly activates: Formation of C5b:C6:C7 complex

Formation of C5b:C6:C7 complex
type: GO_0003674
BFO_0000050: Terminal pathway of complement
directly activates: C7 allows complex to insert into membrane under attack
directly activates: Vitronectin(VTN) binds to C5b:C6:C7

C7 allows complex to insert into membrane under attack
type: GO_0003674
BFO_0000050: Terminal pathway of complement
directly activates: Formation of C5b:C6:C7:C8 complex

Formation of C5b:C6:C7:C8 complex
type: GO_0003674
BFO_0000050: Terminal pathway of complement
directly activates: Creation of the Membrane Attack Complex (MAC)
directly activates: CD59 inhibits MAC formation

Creation of the Membrane Attack Complex (MAC)
type: GO_0003674
BFO_0000050: Terminal pathway of complement

Cleavage of C3 by C3 convertases
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004252
BFO_0000050: Activation of C3 and C5
directly activates: Formation of classic pathway C5 convertase
directly activates: Factor H binds to C3b
directly activates: BiochemicalReaction4196
directly activates: Terminal pathway of complement

Formation of classic pathway C5 convertase
type: GO_0003674
BFO_0000050: Activation of C3 and C5
directly activates: Activation of C5
directly activates: C3 convertases spontaneously dissociate
directly activates: Catalysis390

Activation of C5
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004252
BFO_0000050: Activation of C3 and C5
directly activates: Formation of C5b:C6 complex
directly activates: BiochemicalReaction4195

C3 convertases spontaneously dissociate
type: GO_0003674
BFO_0000050: Regulation of Complement cascade

Factor H binds to C3b
type: GO_0003674
BFO_0000050: Regulation of Complement cascade
directly activates: Complement factor I binds to extracellular Factor H:C3b

Factor H binds host cell surface markers
type: GO_0003674
BFO_0000050: Regulation of Complement cascade
directly activates: Factor H binds to membrane-associated C3b
directly activates: Control76

Factor H binds to membrane-associated C3b
type: GO_0003674
BFO_0000050: Regulation of Complement cascade
directly activates: Complement factor I binds to membrane-associated Factor H:C3b

Factor H binds to C3bBb
type: GO_0003674
BFO_0000050: Regulation of Complement cascade
directly activates: Factor H displaces Bb

Factor H displaces Bb
type: GO_0003674
BFO_0000050: Regulation of Complement cascade

Complement factor I complex formation
type: GO_0003674
BFO_0000050: Regulation of Complement cascade
directly activates: Complement factor I binds to extracellular Factor H:C3b
directly activates: Complement factor I binds to membrane-associated Factor H:C3b

Complement factor I binds to extracellular Factor H:C3b
type: GO_0003674
BFO_0000050: Regulation of Complement cascade
directly activates: Factor I inactivates plasma Factor H-bound C3b
directly activates: Catalysis391

Factor I inactivates plasma Factor H-bound C3b
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Regulation of Complement cascade

Complement factor I binds to membrane-associated Factor H:C3b
type: GO_0003674
BFO_0000050: Regulation of Complement cascade
directly activates: Factor I inactivates Factor H-boundC3b
directly activates: Catalysis392

Factor I inactivates Factor H-boundC3b
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004252
BFO_0000050: Regulation of Complement cascade

iC3b proteolysis
type: GO_0003674
BFO_0000050: Regulation of Complement cascade

CR1 binds C3bBb/C4bC2a
type: GO_0003674
BFO_0000050: Regulation of Complement cascade
directly activates: Displacement of C2a/Bb by CR1

Displacement of C2a/Bb by CR1
type: GO_0003674
BFO_0000050: Regulation of Complement cascade
directly activates: Complement factor I binds to MCP, CR1:C4b, C3b

MCP binds C3b, C4b
type: GO_0003674
BFO_0000050: Regulation of Complement cascade
directly activates: Complement factor I binds to MCP, CR1:C4b, C3b

Complement factor I binds to MCP, CR1:C4b, C3b
type: GO_0003674
BFO_0000050: Regulation of Complement cascade
directly activates: Factor I inactivates MCP/CR1-bound C4b/C3b
directly activates: Catalysis393

Factor I inactivates MCP/CR1-bound C4b/C3b
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004252
BFO_0000050: Regulation of Complement cascade
directly activates: iC3b proteolysis

DAF binds C3bBb, C4bC2a
type: GO_0003674
BFO_0000050: Regulation of Complement cascade
directly activates: DAF accelerates C3bBb/C4bC2a dissociation

DAF accelerates C3bBb/C4bC2a dissociation
type: GO_0003674
BFO_0000050: Regulation of Complement cascade

C4b-binding protein binds C4b
type: GO_0003674
BFO_0000050: Regulation of Complement cascade
directly activates: Complement factor I binds C4BP

Complement factor I binds C4BP
type: GO_0003674
BFO_0000050: Regulation of Complement cascade
directly activates: Complement factor I inactivates C4BP-bound C4b

Complement factor I inactivates C4BP-bound C4b
type: GO_0003674
BFO_0000050: Regulation of Complement cascade

C4b binding protein binds C4bC2a
type: GO_0003674
BFO_0000050: Regulation of Complement cascade
directly activates: C4b binding protein displaces C2a

C4b binding protein displaces C2a
type: GO_0003674
BFO_0000050: Regulation of Complement cascade

C4b binding protein binds Protein S
type: GO_0003674
BFO_0000050: Regulation of Complement cascade

CD59 inhibits MAC formation
type: GO_0003674
BFO_0000050: Regulation of Complement cascade

Formation of soluble VTN:C5b-C9
type: GO_0003674
BFO_0000050: Regulation of Complement cascade

Vitronectin(VTN) binds to C5b:C6:C7
type: GO_0003674
BFO_0000050: Regulation of Complement cascade

Hydrolysis of internal thioester in C4b
type: GO_0003674
BFO_0000050: Regulation of Complement cascade

Complement cascade
type: GO_0008150

Initial triggering of complement
type: GO_0008150
BFO_0000050: Complement cascade

Creation of C4 and C2 activators
type: GO_0008150
BFO_0000050: Initial triggering of complement

Lectin pathway of complement activation
type: GO_0008150
BFO_0000050: Creation of C4 and C2 activators

Ficolins bind to repetitive carbohydrate structures on the target cell surface
type: GO_0008150
BFO_0000050: Lectin pathway of complement activation

Classical antibody-mediated complement activation
type: GO_0008150
BFO_0000050: Creation of C4 and C2 activators

Alternative complement activation
type: GO_0008150
BFO_0000050: Initial triggering of complement

Terminal pathway of complement
type: GO_0008150
BFO_0000050: Complement cascade

Activation of C3 and C5
type: GO_0008150
BFO_0000050: Complement cascade

Regulation of Complement cascade
type: GO_0008150
BFO_0000050: Complement cascade