COMT
label: UniProt:P21964 COMT

DAT1
label: SLC6A3
label: UniProt:Q01959 SLC6A3

Reuptake of dopamine from the synaptic celft into neurons
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: DAT1
type: GO_0008504
BFO_0000050: Clearance of dopamine
directly activates: Enzymatic degradation of dopamine by COMT
directly activates: Enzymatic degradation of Dopamine by monoamine oxidase
label: Reuptake of dopamine from the synaptic cleft into neurons

methylation of Dopamine to form 3-Methoxytyramine
type: Restriction
  on property: enabled by
  some values from: COMT
type: Restriction
  on property: enabled by
  some values from: COMT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0008168
BFO_0000050: Enzymatic degradation of dopamine by COMT

Oxidation of 3-Methoxytyramine to homovanillic acid
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: GO_0008131
BFO_0000050: Enzymatic degradation of dopamine by COMT

oxidation of dopamine to 3,4dihydroxyphenylacetic acid (DOPAC)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: GO_0008131
BFO_0000050: Enzymatic degradation of Dopamine by monoamine oxidase
directly activates: Methylation of 3,4-dihydroxyphenylacetic acid to homovanillic acid
directly activates: Catalysis1668

Methylation of 3,4-dihydroxyphenylacetic acid to homovanillic acid
type: Restriction
  on property: enabled by
  some values from: COMT
type: Restriction
  on property: enabled by
  some values from: COMT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0008168
BFO_0000050: Enzymatic degradation of Dopamine by monoamine oxidase

Clearance of dopamine
type: GO_0008150
label: Dopamine clearance from the synaptic cleft

Enzymatic degradation of dopamine by COMT
type: GO_0008150
BFO_0000050: Clearance of dopamine

Enzymatic degradation of Dopamine by monoamine oxidase
type: GO_0008150
BFO_0000050: Clearance of dopamine