CHEK1
label: CHK1
label: UniProt:O14757 CHEK1

CDS1
label: CHEK2
label: CHK2
label: RAD53
label: UniProt:O96017-12 CHEK2

UniProt:P30291 WEE1
label: WEE1

ATM
label: UniProt:Q13315 ATM

COP1
label: RFWD2
label: RNF200
label: UniProt:Q8NHY2 RFWD2

Phosphorylation of p53 at ser-15 by ATM kinase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Stabilization of p53
directly activates: TemplateReaction149
directly activates: TemplateReaction151
directly activates: TemplateReactionRegulation173
directly activates: TemplateReactionRegulation175

Phosphorylation of MDM2 at serine-395 by ATM kinase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Stabilization of p53

Phosphorylation of COP1 at Ser-387 by ATM
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Autodegradation of the E3 ubiquitin ligase COP1
directly activates: Dissociation of the COP1-p53 complex
directly activates: Translocation of COP1 from the nucleus to the cytoplasm

Dissociation of the COP1-p53 complex
type: GO_0003674
BFO_0000050: Autodegradation of the E3 ubiquitin ligase COP1

Translocation of COP1 from the nucleus to the cytoplasm
type: GO_0003674
BFO_0000050: Autodegradation of the E3 ubiquitin ligase COP1
directly activates: Autoubiquitination of phospho-COP1(Ser-387 )
directly activates: Catalysis806

Autoubiquitination of phospho-COP1(Ser-387 )
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: COP1
type: Restriction
  on property: enabled by
  some values from: COP1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: COP1
type: Restriction
  on property: enabled by
  some values from: COP1
type: Restriction
  on property: enabled by
  some values from: COP1
type: Restriction
  on property: enabled by
  some values from: COP1
type: Restriction
  on property: enabled by
  some values from: COP1
type: Restriction
  on property: enabled by
  some values from: COP1
type: Restriction
  on property: enabled by
  some values from: COP1
type: Restriction
  on property: enabled by
  some values from: COP1
type: Restriction
  on property: enabled by
  some values from: COP1
type: Restriction
  on property: enabled by
  some values from: COP1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: COP1
type: Restriction
  on property: enabled by
  some values from: COP1
type: Restriction
  on property: enabled by
  some values from: COP1
type: Restriction
  on property: enabled by
  some values from: COP1
type: Restriction
  on property: enabled by
  some values from: COP1
type: Restriction
  on property: enabled by
  some values from: COP1
type: Restriction
  on property: enabled by
  some values from: COP1
type: Restriction
  on property: enabled by
  some values from: COP1
type: Restriction
  on property: enabled by
  some values from: COP1
type: Restriction
  on property: enabled by
  some values from: COP1
type: Restriction
  on property: enabled by
  some values from: COP1
type: Restriction
  on property: enabled by
  some values from: COP1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: COP1
type: Restriction
  on property: enabled by
  some values from: COP1
type: Restriction
  on property: enabled by
  some values from: COP1
type: Restriction
  on property: enabled by
  some values from: COP1
type: Restriction
  on property: enabled by
  some values from: COP1
type: Restriction
  on property: enabled by
  some values from: COP1
type: Restriction
  on property: enabled by
  some values from: COP1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: COP1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004842
BFO_0000050: Autodegradation of the E3 ubiquitin ligase COP1
directly activates: Proteasome mediated degradation of COP1
directly activates: Catalysis807

Proteasome mediated degradation of COP1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004175
BFO_0000050: Autodegradation of the E3 ubiquitin ligase COP1

Inactivation of Cyclin E:Cdk2 complexes by p27/p21
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004861
BFO_0000050: p53-Dependent G1 DNA Damage Response
directly activates: BiochemicalReaction1894
directly activates: Catalysis831

Phosphorylation of Cdc25A at Ser-123 in response to DNA damage
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: p53-Independent DNA Damage Response

Phosphorylation of Cdc25A at Ser-123 by Chk2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: CDS1
type: Restriction
  on property: enabled by
  some values from: CDS1
type: Restriction
  on property: enabled by
  some values from: CDS1
type: Restriction
  on property: enabled by
  some values from: CDS1
type: Restriction
  on property: enabled by
  some values from: CDS1
type: Restriction
  on property: enabled by
  some values from: CDS1
type: Restriction
  on property: enabled by
  some values from: CDS1
type: Restriction
  on property: enabled by
  some values from: CDS1
type: Restriction
  on property: enabled by
  some values from: CDS1
type: Restriction
  on property: enabled by
  some values from: CDS1
type: Restriction
  on property: enabled by
  some values from: CDS1
type: Restriction
  on property: enabled by
  some values from: CDS1
type: Restriction
  on property: enabled by
  some values from: CDS1
type: Restriction
  on property: enabled by
  some values from: CDS1
type: Restriction
  on property: enabled by
  some values from: CDS1
type: Restriction
  on property: enabled by
  some values from: CDS1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Ubiquitin Mediated Degradation of Phosphorylated Cdc25A

Ubiquitination of phosphorylated Cdc25A
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004842
BFO_0000050: Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
directly activates: Proteolytic degradation of ubiquitinated-Cdc25A
directly activates: Catalysis812

Proteolytic degradation of ubiquitinated-Cdc25A
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004175
BFO_0000050: Ubiquitin Mediated Degradation of Phosphorylated Cdc25A

Phosphorylation and activation of Chk1 by ATM
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
directly activates: Phosphorylation of Cdc25A at Ser-123 by Chk1
directly activates: Phosphorylation of Wee1 kinase by Chk1
directly activates: Phosphorylation of Cdc25C at Ser 216 by Chk1
directly activates: Catalysis814
directly activates: Catalysis818
directly activates: Catalysis822

Phosphorylation of Cdc25A at Ser-123 by Chk1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: CHEK1
type: Restriction
  on property: enabled by
  some values from: CHEK1
type: Restriction
  on property: enabled by
  some values from: CHEK1
type: Restriction
  on property: enabled by
  some values from: CHEK1
type: Restriction
  on property: enabled by
  some values from: CHEK1
type: Restriction
  on property: enabled by
  some values from: CHEK1
type: Restriction
  on property: enabled by
  some values from: CHEK1
type: Restriction
  on property: enabled by
  some values from: CHEK1
type: Restriction
  on property: enabled by
  some values from: CHEK1
type: Restriction
  on property: enabled by
  some values from: CHEK1
type: Restriction
  on property: enabled by
  some values from: CHEK1
type: Restriction
  on property: enabled by
  some values from: CHEK1
type: Restriction
  on property: enabled by
  some values from: CHEK1
type: Restriction
  on property: enabled by
  some values from: CHEK1
type: Restriction
  on property: enabled by
  some values from: CHEK1
type: Restriction
  on property: enabled by
  some values from: CHEK1
type: Restriction
  on property: enabled by
  some values from: CHEK1
type: Restriction
  on property: enabled by
  some values from: CHEK1
type: Restriction
  on property: enabled by
  some values from: CHEK1
type: Restriction
  on property: enabled by
  some values from: CHEK1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
BFO_0000050: Activation of ATR in response to replication stress

Recruitment and activation of Chk1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
type: GO_0006260
BFO_0000050: G2/M DNA damage checkpoint
BFO_0000050: Activation of ATR in response to replication stress
directly activates: Phosphorylation of Cdc25A at Ser-123 by Chk1
directly activates: Phosphorylation of Cdc25C at Ser 216 by Chk1
directly activates: Catalysis814
directly activates: Catalysis822

Phosphorylation and activation of CHK2 by ATM
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: GO_0016301
BFO_0000050: G2/M DNA damage checkpoint
directly activates: Phosphorylation of Cdc25A at Ser-123 by Chk2
directly activates: Catalysis810

Phosphorylation of Cdc25C at Ser216
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
directly activates: Association of phospho-Cdc25C(Ser 216) with 14-3-3 proteins

Association of phospho-Cdc25C(Ser 216) with 14-3-3 proteins
type: GO_0003674
BFO_0000050: Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
directly activates: Retention of phospho-Cdc25C:14-3-3 complexes within the cytoplasm

Retention of phospho-Cdc25C:14-3-3 complexes within the cytoplasm
type: GO_0003674
BFO_0000050: Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex

Phosphorylation of Wee1 kinase by Chk1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: CHEK1
type: Restriction
  on property: enabled by
  some values from: CHEK1
type: Restriction
  on property: enabled by
  some values from: CHEK1
type: Restriction
  on property: enabled by
  some values from: CHEK1
type: Restriction
  on property: enabled by
  some values from: CHEK1
type: Restriction
  on property: enabled by
  some values from: CHEK1
type: Restriction
  on property: enabled by
  some values from: CHEK1
type: Restriction
  on property: enabled by
  some values from: CHEK1
type: GO_0016301
BFO_0000050: Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
directly activates: Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes
directly activates: Catalysis819

Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: UniProt:P30291 WEE1
type: Restriction
  on property: enabled by
  some values from: UniProt:P30291 WEE1
type: Restriction
  on property: enabled by
  some values from: UniProt:P30291 WEE1
type: Restriction
  on property: enabled by
  some values from: UniProt:P30291 WEE1
type: Restriction
  on property: enabled by
  some values from: UniProt:P30291 WEE1
type: Restriction
  on property: enabled by
  some values from: UniProt:P30291 WEE1
type: Restriction
  on property: enabled by
  some values from: UniProt:P30291 WEE1
type: Restriction
  on property: enabled by
  some values from: UniProt:P30291 WEE1
type: Restriction
  on property: enabled by
  some values from: UniProt:P30291 WEE1
type: Restriction
  on property: enabled by
  some values from: UniProt:P30291 WEE1
type: Restriction
  on property: enabled by
  some values from: UniProt:P30291 WEE1
type: Restriction
  on property: enabled by
  some values from: UniProt:P30291 WEE1
type: GO_0016301
BFO_0000050: Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
BFO_0000050: G2/M DNA replication checkpoint
directly activates: BiochemicalReaction1942
directly activates: Control139

Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes
type: GO_0003674
BFO_0000050: G2/M DNA replication checkpoint
directly activates: BiochemicalReaction1940
directly activates: BiochemicalReaction1950
directly activates: Catalysis864

Stalling of DNA replication fork and RPA binding
type: GO_0006260
BFO_0000050: Activation of ATR in response to replication stress
directly activates: Binding of ATR-ATRIP to the RPA-ssDNA complex
directly activates: Recruitment of Rad17-RFC complex to DNA

Binding of ATR-ATRIP to the RPA-ssDNA complex
type: GO_0006260
BFO_0000050: Activation of ATR in response to replication stress
directly activates: Activation of claspin
directly activates: Catalysis821

Recruitment of Rad17-RFC complex to DNA
type: GO_0006260
BFO_0000050: Activation of ATR in response to replication stress
directly activates: Recruitment of the 9-1-1 complex to DNA
directly activates: Catalysis820

Recruitment of the 9-1-1 complex to DNA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003689
type: GO_0006260
BFO_0000050: Activation of ATR in response to replication stress
directly activates: Recruitment and activation of Chk1
directly activates: Catalysis815
label: Recruitment of the Rad9-Hus1-Rad1 complex to DNA

Loading of claspin onto DNA during replication origin firing
type: GO_0006260
BFO_0000050: Activation of ATR in response to replication stress
directly activates: Activation of claspin
directly activates: Catalysis821

Activation of claspin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
type: GO_0006260
BFO_0000050: Activation of ATR in response to replication stress
directly activates: Recruitment and activation of Chk1
directly activates: Catalysis815

Phosphorylation of Cdc25C at Ser 216 by Chk1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: CHEK1
type: Restriction
  on property: enabled by
  some values from: CHEK1
type: Restriction
  on property: enabled by
  some values from: CHEK1
type: Restriction
  on property: enabled by
  some values from: CHEK1
type: GO_0004674
BFO_0000050: Activation of ATR in response to replication stress

Mad1 binds kinetochore
type: GO_0003674
BFO_0000050: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
directly activates: MAD2 associates with the Mad1 kinetochore complex

MAD2 associates with the Mad1 kinetochore complex
type: GO_0003674
BFO_0000050: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
directly activates: MAD2 converted to an inhibitory state via interaction with Mad1

MAD2 converted to an inhibitory state via interaction with Mad1
type: GO_0003674
BFO_0000050: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
directly activates: Release of activated MAD2 from kinetochores

Release of activated MAD2 from kinetochores
type: GO_0003674
BFO_0000050: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
directly activates: Inactivation of APC/C via CDC20 sequestration
directly activates: Formation of the MCC complex
directly activates: Inactivation of APC/C via direct inhibition of the APC/C complex

Inactivation of APC/C via CDC20 sequestration
type: GO_0003674
BFO_0000050: Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components

Formation of the MCC complex
type: GO_0003674
BFO_0000050: Inactivation of APC/C via direct inhibition of the APC/C complex
directly activates: Binding of the MCC complex to the APC/C complex

Binding of the MCC complex to the APC/C complex
type: GO_0003674
BFO_0000050: Inactivation of APC/C via direct inhibition of the APC/C complex
directly activates: BiochemicalReaction2028
directly activates: BiochemicalReaction2520
directly activates: BiochemicalReaction3794

Cell Cycle Checkpoints
type: GO_0008150

G1/S DNA Damage Checkpoints
type: GO_0008150
BFO_0000050: Cell Cycle Checkpoints

p53-Dependent G1/S DNA damage checkpoint
type: GO_0008150
BFO_0000050: G1/S DNA Damage Checkpoints

p53-Dependent G1 DNA Damage Response
type: GO_0008150
BFO_0000050: p53-Dependent G1/S DNA damage checkpoint

Stabilization of p53
type: GO_0008150
BFO_0000050: p53-Dependent G1 DNA Damage Response

Autodegradation of the E3 ubiquitin ligase COP1
type: GO_0008150
BFO_0000050: Stabilization of p53

Transcriptional activation of p53 responsive genes
type: GO_0008150
BFO_0000050: p53-Dependent G1 DNA Damage Response

Transcriptional activation of cell cycle inhibitor p21
type: GO_0008150
BFO_0000050: Transcriptional activation of p53 responsive genes

p53-Independent G1/S DNA damage checkpoint
type: GO_0008150
BFO_0000050: G1/S DNA Damage Checkpoints

p53-Independent DNA Damage Response
type: GO_0008150
BFO_0000050: p53-Independent G1/S DNA damage checkpoint

Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
type: GO_0008150
BFO_0000050: p53-Independent DNA Damage Response

G2/M Checkpoints
type: GO_0008150
BFO_0000050: Cell Cycle Checkpoints

G2/M DNA damage checkpoint
type: GO_0008150
BFO_0000050: G2/M Checkpoints

Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
type: GO_0008150
BFO_0000050: G2/M DNA damage checkpoint

G2/M DNA replication checkpoint
type: GO_0008150
BFO_0000050: G2/M Checkpoints

Activation of ATR in response to replication stress
type: GO_0008150
BFO_0000050: G2/M Checkpoints

Mitotic Spindle Checkpoint
type: GO_0008150
BFO_0000050: Cell Cycle Checkpoints

Amplification of signal from the kinetochores
type: GO_0008150
BFO_0000050: Mitotic Spindle Checkpoint

Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
type: GO_0008150
BFO_0000050: Amplification of signal from the kinetochores

Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
type: GO_0008150
BFO_0000050: Mitotic Spindle Checkpoint

Inactivation of APC/C via direct inhibition of the APC/C complex
type: GO_0008150
BFO_0000050: Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components

Transcriptional activation of p21 by p53 after DNA damage
type: GO_0003674
BFO_0000050: Transcriptional activation of cell cycle inhibitor p21