PAK2
label: UniProt:Q13177 PAK2

Caspase-mediated cleavage of alpha adducin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Caspase-mediated cleavage of cytoskeletal proteins

Caspase mediated cleavage of alpha-II-Fodrin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Caspase-mediated cleavage of cytoskeletal proteins

Caspase-mediated cleavage of GAS2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Caspase-mediated cleavage of cytoskeletal proteins

Caspase mediated cleavage of HIP-55
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Caspase-mediated cleavage of cytoskeletal proteins

Caspase-mediated cleavage of vimentin at DSVD (85)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Caspase-mediated cleavage of cytoskeletal proteins

Caspase mediated cleavage of vimentin at IDVD (259)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Caspase-mediated cleavage of cytoskeletal proteins

Caspase-mediated cleavage of vimentin at TNLD (429)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Caspase-mediated cleavage of cytoskeletal proteins

Caspase-mediated cleavage of gelsolin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Caspase-mediated cleavage of cytoskeletal proteins

Caspase-mediated cleavage of plectin-1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Caspase-mediated cleavage of cytoskeletal proteins

Caspase-mediated cleavage of Tau
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Caspase-mediated cleavage of cytoskeletal proteins

Caspase-mediated cleavage of E-Cadherin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004197
BFO_0000050: Apoptotic cleavage of cell adhesion proteins

Caspase mediated cleavage of beta-catenin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Apoptotic cleavage of cell adhesion proteins

Caspase-mediated cleavage of Desmoglein 3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004197
BFO_0000050: Apoptotic cleavage of cell adhesion proteins

Caspase-mediated cleavage of Desmoglein 2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004197
BFO_0000050: Apoptotic cleavage of cell adhesion proteins

Caspase-mediated cleavage of Desmoglein 1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004197
BFO_0000050: Apoptotic cleavage of cell adhesion proteins

Caspase-mediated cleavage of Desmoplakin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004197
BFO_0000050: Apoptotic cleavage of cell adhesion proteins

Caspase-mediated cleavage of plakophilin-1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004197
BFO_0000050: Apoptotic cleavage of cell adhesion proteins

Caspase-mediated cleavage of TJP1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004197
BFO_0000050: Apoptotic cleavage of cell adhesion proteins

Caspase-mediated cleavage of Z0-2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004197
BFO_0000050: Apoptotic cleavage of cell adhesion proteins

Caspase-mediated cleavage of occludin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004197
BFO_0000050: Apoptotic cleavage of cell adhesion proteins

Caspase-mediated cleavage of Lamin A
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004197
BFO_0000050: Breakdown of the nuclear lamina

Caspase-mediated cleavage of Lamin B1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004197
BFO_0000050: Breakdown of the nuclear lamina

Caspase mediated cleavage of APC
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Apoptotic cleavage of cellular proteins

Caspase mediated cleavage of C-IAP1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Apoptotic cleavage of cellular proteins

Caspase-mediated cleavage of FADK 1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Apoptotic cleavage of cellular proteins

Caspase 3-mediated cleavage of PKC delta
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Apoptotic cleavage of cellular proteins

Caspase-mediated cleavage of PKC theta
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Apoptotic cleavage of cellular proteins

Caspase-mediated cleavage of Acinus
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Apoptotic cleavage of cellular proteins

Caspase-mediated cleavage of Rock-1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Apoptotic cleavage of cellular proteins

Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Apoptotic cleavage of cellular proteins

Caspase mediated cleavage of BAP31
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: GO_0004197
BFO_0000050: Apoptotic cleavage of cellular proteins
directly activates: Mitochondrial recruitment of Drp1

Caspase-mediated cleavage of Etk
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Apoptotic cleavage of cellular proteins

Caspase-mediated cleavage of MASK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Apoptotic cleavage of cellular proteins

Caspase-mediated cleavage of MST3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Apoptotic cleavage of cellular proteins
directly activates: Nuclear translocation of catalytic domain of Mst3

Caspase-mediated cleavage of claspin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004197
BFO_0000050: Apoptotic cleavage of cellular proteins

Cleavage of Satb1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004197
BFO_0000050: Apoptotic cleavage of cellular proteins

Association of DFF40 with DFF45
type: GO_0003674
BFO_0000050: Activation of DNA fragmentation factor
directly activates: Association of DFF with alpha:beta importin

Association of DFF with alpha:beta importin
type: GO_0003674
BFO_0000050: Activation of DNA fragmentation factor
directly activates: Translocation of DFF to the nucleus

Translocation of DFF to the nucleus
type: GO_0003674
BFO_0000050: Activation of DNA fragmentation factor
directly activates: Caspase 3-mediated cleavage of DFF45 (117)
directly activates: Catalysis3152

Translocation of caspase-3 to the nucleus
type: GO_0003674
BFO_0000050: Activation of DNA fragmentation factor
directly activates: Caspase 3-mediated cleavage of DFF45 (117)
directly activates: Catalysis3152

Caspase 3-mediated cleavage of DFF45 (117)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004197
BFO_0000050: Activation of DNA fragmentation factor
directly activates: Cleavage of DFF45 (224) by caspase-3
directly activates: Catalysis3153

Cleavage of DFF45 (224) by caspase-3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004197
BFO_0000050: Activation of DNA fragmentation factor
directly activates: Cleaved fragments of DFF45 dissociate from DFF40

Cleaved fragments of DFF45 dissociate from DFF40
type: GO_0003674
BFO_0000050: Activation of DNA fragmentation factor
directly activates: Homodimerization of DFF40

Homodimerization of DFF40
type: GO_0003674
BFO_0000050: Activation of DNA fragmentation factor
directly activates: Association of DFF40 with chromatin

Association of DFF40 with chromatin
type: GO_0003674
BFO_0000050: Activation of DNA fragmentation factor
directly activates: Cleavage of DNA by DFF40
directly activates: Catalysis3154
directly activates: Control498

Association of HMGB1/HMGB2 with chromatin
type: GO_0003674
BFO_0000050: Activation of DNA fragmentation factor

Cleavage of DNA by DFF40
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004536
BFO_0000050: Activation of DNA fragmentation factor

Cleavage of PAK-2 at 212
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Stimulation of the cell death response by PAK-2p34
directly activates: Autophosphorylation of PAK-2p34 in the activation loop
directly activates: Catalysis3156

Autophosphorylation of PAK-2p34 in the activation loop
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: PAK2
type: Restriction
  on property: enabled by
  some values from: PAK2
type: GO_0016301
BFO_0000050: Stimulation of the cell death response by PAK-2p34
directly activates: Proteolytic PAK-2p34 fragment translocates to the nucleus
directly activates: BiochemicalReaction6091
directly activates: BiochemicalReaction6093
directly activates: Catalysis3158

Proteolytic PAK-2p34 fragment translocates to the nucleus
type: GO_0003674
BFO_0000050: Stimulation of the cell death response by PAK-2p34

Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: PAK2
type: Restriction
  on property: enabled by
  some values from: PAK2
type: GO_0016301
BFO_0000050: Stimulation of the cell death response by PAK-2p34
directly activates: Cleavage of PAK-2 at 212
directly activates: Catalysis3155

Translocation of active caspase-8 to the mitochondrial membrane
type: GO_0003674
BFO_0000050: Apoptotic execution phase
directly activates: Caspase mediated cleavage of BAP31
directly activates: Catalysis3146

Mitochondrial recruitment of Drp1
type: GO_0003674
BFO_0000050: Apoptotic execution phase

Nuclear translocation of catalytic domain of Mst3
type: GO_0003674
BFO_0000050: Apoptotic execution phase

Apoptotic execution phase
type: GO_0008150

Apoptotic cleavage of cellular proteins
type: GO_0008150
BFO_0000050: Apoptotic execution phase

Caspase-mediated cleavage of cytoskeletal proteins
type: GO_0008150
BFO_0000050: Apoptotic cleavage of cellular proteins

Apoptotic cleavage of cell adhesion proteins
type: GO_0008150
BFO_0000050: Apoptotic cleavage of cellular proteins

Breakdown of the nuclear lamina
type: GO_0008150
BFO_0000050: Apoptotic cleavage of cellular proteins

Apoptosis induced DNA fragmentation
type: GO_0008150
BFO_0000050: Apoptotic execution phase

Activation of DNA fragmentation factor
type: GO_0008150
BFO_0000050: Apoptosis induced DNA fragmentation

Stimulation of the cell death response by PAK-2p34
type: GO_0008150
BFO_0000050: Apoptotic execution phase