ART1
UniProt:P52961 ART1
Pro-HNP1-4 are cleaved to biologically active defensin
HNP1-4 are stored in primary neutrophil granules
HNP1-4 are released into phagocytic vacuoles
pro-defensin alpha 5 is stored in Paneth cell granules
pro-defensin alpha 5 is secreted
pro-HD5 is cleaved by trypsin
Alpha-defensins form biologically active dimers
Alpha-defensin dimers adsorb onto microbial membrane anionic phospholipids
Alpha-defensin dimers multimerize to form a pore complex
HNP1-3 bind gp120
HNP1-3 bind CD4
ADP-Ribosylation of HNP-1
Alpha-defensins