ART1
label: UniProt:P52961 ART1

Pro-HNP1-4 are cleaved to biologically active defensin
type: GO_0003674
BFO_0000050: Alpha-defensins
directly activates: HNP1-4 are stored in primary neutrophil granules

HNP1-4 are stored in primary neutrophil granules
type: GO_0003674
BFO_0000050: Alpha-defensins
directly activates: HNP1-4 are released into phagocytic vacuoles

HNP1-4 are released into phagocytic vacuoles
type: GO_0003674
BFO_0000050: Alpha-defensins
directly activates: Alpha-defensins form biologically active dimers
directly activates: HNP1-3 bind gp120
directly activates: HNP1-3 bind CD4
directly activates: ADP-Ribosylation of HNP-1
directly activates: Catalysis412

pro-defensin alpha 5 is stored in Paneth cell granules
type: GO_0003674
BFO_0000050: Alpha-defensins
directly activates: pro-defensin alpha 5 is secreted

pro-defensin alpha 5 is secreted
type: GO_0003674
BFO_0000050: Alpha-defensins
directly activates: pro-HD5 is cleaved by trypsin
directly activates: Catalysis411

pro-HD5 is cleaved by trypsin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0008236
BFO_0000050: Alpha-defensins
directly activates: Alpha-defensins form biologically active dimers

Alpha-defensins form biologically active dimers
type: GO_0003674
BFO_0000050: Alpha-defensins
directly activates: Alpha-defensin dimers adsorb onto microbial membrane anionic phospholipids

Alpha-defensin dimers adsorb onto microbial membrane anionic phospholipids
type: GO_0003674
BFO_0000050: Alpha-defensins
directly activates: Alpha-defensin dimers multimerize to form a pore complex

Alpha-defensin dimers multimerize to form a pore complex
type: GO_0003674
BFO_0000050: Alpha-defensins

HNP1-3 bind gp120
type: GO_0003674
BFO_0000050: Alpha-defensins

HNP1-3 bind CD4
type: GO_0003674
BFO_0000050: Alpha-defensins

ADP-Ribosylation of HNP-1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: ART1
type: GO_0006471
BFO_0000050: Alpha-defensins

Alpha-defensins
type: GO_0008150