# molecular_function 20140730: STRPU_STRPU_H3ITX9 lost/modified serine-type endopeptidase activity (GO:0004252) capacity 20140730: RAT_Klk5l lost/modified serine-type endopeptidase activity (GO:0004252) capacity 20140730: RAT_M0RCD5 lost/modified serine-type endopeptidase activity (GO:0004252) capacity 20140730: MACMU_MACMU_F6QBI7 lost/modified serine-type endopeptidase activity (GO:0004252) capacity 20140730: Theria _PTN000666984 lost/modified serine-type endopeptidase activity (GO:0004252) capacity 20140730: Has function threonine-type endopeptidase activity (GO:0004298) in Eutheria_PTN000666829 20140730: Euarchontoglires_PTN000666830 lost/modified serine-type endopeptidase activity (GO:0004252) capacity 20140730: Has function serine-type endopeptidase activity (GO:0004252) in Opisthokonta_PTN001207579 # cellular_component # biological_process # Pruned from tree 20140730: Pruned PTN001546584 20140730: Pruned PTN001546582 20140730: Pruned PTN001546577 20140730: Pruned Deuterostomia_PTN001546585 20140730: Pruned PTN001546586 # Notes Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).