# molecular_function
20150116: Eutheria_PTN000357511 has function protein binding, bridging (GO:0030674)
20150116: Eutheria_PTN000357511 has function structural molecule activity (GO:0005198)
# cellular_component
20150116: Eutheria_PTN000357511 located in cornified envelope (GO:0001533)
# biological_process
20150116: Eutheria_PTN000357511 participates in keratinocyte differentiation (GO:0030216)
20150116: Eutheria_PTN000357511 participates in isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine (GO:0018153)
# Notes



Annotation inferences using phylogenetic trees

The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).