# HISTORY 26 Apr 2016: Updated by: TOUCHUP-v1.15 20 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function # cellular_component # biological_process 20160229: Gammaproteobacteria_PTN002218428 participates in succinate metabolic process (GO:0006105) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES Note that the E.coli sequence P64559 (CPTB_ECOLI) from Escherichia coli (strain K12) has the name "Antitoxin CptB", aka cptB. However, it is named in the tree as sdhE. TrEMBL sequences from E.coli with the name sdhE include these two: - A0A0S1EXE7 (A0A0S1EXE7_ECOLI) from Escherichia coli (strain K12) -- Submitted name: Flavinator of succinate dehydrogenase antitoxin of CptAB toxin-antitoxin pair protein - A0A0E1M300 (A0A0E1M300_ECOLX) from Escherichia coli 1303 -- Submitted name: Flavinator of succinate dehydrogenase, antitoxin of CptAB toxin-antitoxin pair All three sequences have identical sequences. # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).