# HISTORY 16 Sep 2016: Saved by mfeuerma using Paint 2.22 # molecular_function 20160916: Metazoa_PTN002025641 has function signal transducer activity (GO:0004871) # cellular_component # biological_process 20160916: Metazoa_PTN002025641 participates in positive regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043123) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).