# HISTORY 27 Mar 2016: Updated by: TOUCHUP-v1.15 18 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20141210: Bilateria_PTN000694106 has function transcription cofactor activity (GO:0003712) 20141210: Euteleostomi_PTN000694265 has function estrogen receptor binding (GO:0030331) 20141210: Euteleostomi_PTN000694265 has function transcription corepressor activity (GO:0003714) # cellular_component 20141210: Bilateria_PTN000694106 is found in nucleus (GO:0005634) # biological_process 20141210: Bilateria_PTN000694106 participates in regulation of transcription from RNA polymerase II promoter (GO:0006357) 20141210: Euteleostomi_PTN000694265 participates in negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147) 20141210: Euteleostomi_PTN000694265 participates in response to estrogen (GO:0043627) 20141210: Euteleostomi_PTN000694265 participates in negative regulation of transcription from RNA polymerase II promoter (GO:0000122) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).