# HISTORY
08 May 2016: Updated by: TOUCHUP-v1.18
18 Mar 2016: Updated by: TOUCHUP-v1.14
27 Mar 2016: Updated by: TOUCHUP-v1.15

# molecular_function
20150918: Boreoeutheria_PTN000690193 has function interleukin-1 receptor binding (GO:0005149) 
20150918: Euteleostomi_PTN000690155 has function epidermal growth factor receptor binding (GO:0005154) 
20150918: Bilateria_PTN001556866 has function Roundabout binding (GO:0048495) 
20150918: Bilateria_PTN001556866 has function heparin binding (GO:0008201) 
20150918: Euteleostomi_PTN000689792 has function heparin binding (GO:0008201) 
20150918: Euteleostomi_PTN000689694 has function collagen binding (GO:0005518) 
20150918: Euteleostomi_PTN000707219 has function heparin binding (GO:0008201) 
20150918: Euteleostomi_PTN000707219 has function collagen V binding (GO:0070052) 
20150918: Euteleostomi_PTN000689642 has LOST/MODIFIED function Roundabout binding (GO:0048495) 
20150918: Chordata_PTN001971514 has LOST/MODIFIED function Roundabout binding (GO:0048495) 
20150918: Euteleostomi_PTN000689667 has LOST/MODIFIED function Roundabout binding (GO:0048495) 

# cellular_component
20150918: Boreoeutheria_PTN000690193 is found in plasma membrane (GO:0005886) 
20150918: Eumetazoa_PTN001224703 is found in proteinaceous extracellular matrix (GO:0005578) 
20150918: Eumetazoa_PTN001224703 is found in extracellular space (GO:0005615) 
20150918: Chromadorea_PTN001224501 is found in plasma membrane (GO:0005886) 
20150918: Euteleostomi_PTN000689792 is found in extracellular exosome (GO:0070062) 
20150918: Euteleostomi_PTN000690321 is found in integral component of plasma membrane (GO:0005887) 
20150918: Chromadorea_PTN001224501 is NOT found in proteinaceous extracellular matrix (GO:0005578) 
20150918: Chromadorea_PTN001224501 is NOT found in extracellular space (GO:0005615) 

# biological_process
20150918: node_PTN000689992 participates in axonogenesis (GO:0007409) 
20150923: Boreoeutheria_PTN000690193 participates in toll-like receptor signaling pathway (GO:0002224) 
20150923: Boreoeutheria_PTN000690193 participates in response to molecule of bacterial origin (GO:0002237) 
20150923: Euteleostomi_PTN000690155 participates in signal transduction (GO:0007165) 
20150923: Bilateria_PTN001556866 participates in axon extension involved in axon guidance (GO:0048846) 
20150918: Bilateria_PTN001556866 participates in regulation of axonogenesis (GO:0050770) 
20150923: Bilateria_PTN001556866 participates in Roundabout signaling pathway (GO:0035385) 
20150923: Euteleostomi_PTN000690515 participates in retinal ganglion cell axon guidance (GO:0031290) 
20150923: Euteleostomi_PTN000690515 participates in central nervous system projection neuron axonogenesis (GO:0021952) 
20150923: Euteleostomi_PTN000690515 participates in negative regulation of cell growth (GO:0030308) 
20150918: Euteleostomi_PTN000690187 does NOT participate in axonogenesis (GO:0007409) 
20150918: Bilateria_PTN000689595 does NOT participate in axonogenesis (GO:0007409) 
20150923: Euteleostomi_PTN000689642 does NOT participate in axon extension involved in axon guidance (GO:0048846) 
20150918: Euteleostomi_PTN000689642 does NOT participate in regulation of axonogenesis (GO:0050770) 
20150923: Euteleostomi_PTN000689642 does NOT participate in Roundabout signaling pathway (GO:0035385) 
20150918: Euteleostomi_PTN000690488 does NOT participate in axonogenesis (GO:0007409) 
20150923: Chordata_PTN001971514 does NOT participate in axon extension involved in axon guidance (GO:0048846) 
20150918: Chordata_PTN001971514 does NOT participate in regulation of axonogenesis (GO:0050770) 
20150923: Chordata_PTN001971514 does NOT participate in Roundabout signaling pathway (GO:0035385) 
20150918: node_PTN001971448 does NOT participate in axonogenesis (GO:0007409) 
20150918: Euteleostomi_PTN000690132 does NOT participate in axonogenesis (GO:0007409) 
20150918: node_PTN001224716 does NOT participate in axonogenesis (GO:0007409) 
20150918: Euteleostomi_PTN000690075 does NOT participate in axonogenesis (GO:0007409) 
20150923: Euteleostomi_PTN000689667 does NOT participate in axon extension involved in axon guidance (GO:0048846) 
20150918: Euteleostomi_PTN000689667 does NOT participate in regulation of axonogenesis (GO:0050770) 
20150923: Euteleostomi_PTN000689667 does NOT participate in Roundabout signaling pathway (GO:0035385) 
20150918: Euteleostomi_PTN000689599 does NOT participate in axonogenesis (GO:0007409) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).