# HISTORY
08 May 2016: Updated by: TOUCHUP-v1.18
18 Mar 2016: Updated by: TOUCHUP-v1.14
18 Nov 2015: redistribution of PTN000043896 from PTHR10385 to PTHR24369
27 Mar 2016: Updated by: TOUCHUP-v1.15

# molecular_function
20141113: Eukaryota_PTN000043893 has function protein kinase inhibitor activity (GO:0004860) 

# cellular_component
20141113: Eukaryota_PTN000043893 is found in cytoplasm (GO:0005737) 

# biological_process
20141113: Eukaryota_PTN000043893 participates in negative regulation of protein kinase activity (GO:0006469) 
20141113: Eukaryota_PTN000043893 participates in negative regulation of JAK-STAT cascade (GO:0046426) 
20141113: Eukaryota_PTN000043893 participates in cytokine-mediated signaling pathway (GO:0019221) 
20141113: Eumetazoa_PTN000822858 participates in negative regulation of epidermal growth factor receptor signaling pathway (GO:0042059) 
20141114: node_PTN000043896 participates in negative regulation of insulin receptor signaling pathway (GO:0046627) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
Nov 14 2014 - HM

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).