# HISTORY
08 May 2016: Updated by: TOUCHUP-v1.18
18 Mar 2016: Updated by: TOUCHUP-v1.14
27 Mar 2016: Updated by: TOUCHUP-v1.15

# molecular_function
20150429: root_PTN000683254 has function protein serine/threonine kinase activity (GO:0004674) 
20150429: Euteleostomi_PTN000683556 has function microtubule binding (GO:0008017) 
20150429: Chordata_PTN001219961 has function sodium channel regulator activity (GO:0017080) 
20150429: Chordata_PTN001219961 has function chloride channel regulator activity (GO:0017081) 
20150429: Chordata_PTN001219961 has function calcium channel regulator activity (GO:0005246) 
20150429: Chordata_PTN001219961 has function potassium channel regulator activity (GO:0015459) 

# cellular_component
20150429: root_PTN000683254 is found in intracellular (GO:0005622) 
20150429: Amniota_PTN000683385 is found in spindle pole (GO:0000922) 
20150429: Euteleostomi_PTN001219866 is found in spindle pole (GO:0000922) 
20150429: Euteleostomi_PTN001219866 is found in nucleus (GO:0005634) 
20150429: Fungi_PTN001220116 is found in cytoplasm (GO:0005737) 
20150429: Fungi_PTN001220116 is found in nucleus (GO:0005634) 
20150429: Euteleostomi_PTN000683556 is found in microtubule cytoskeleton (GO:0015630) 
20150429: Opisthokonta_PTN001220094 is found in nucleus (GO:0005634) 
20150429: Fungi_PTN001220075 is found in spindle pole body (GO:0005816) 
20150429: Amniota_PTN001553943 is found in integral component of mitochondrial outer membrane (GO:0031307) 
20150429: Amniota_PTN001553943 is found in nuclear membrane (GO:0031965) 
20150429: Amniota_PTN001553943 is found in sarcoplasmic reticulum membrane (GO:0033017) 
20150429: Amniota_PTN001553943 is found in plasma membrane (GO:0005886) 
20150429: Euteleostomi_PTN000683297 is found in cytoplasmic, membrane-bounded vesicle (GO:0016023) 
20150429: Euteleostomi_PTN001553825 is found in nucleus (GO:0005634) 
20150429: Euteleostomi_PTN001553825 is found in cytoplasm (GO:0005737) 

# biological_process
20150429: root_PTN000683254 participates in peptidyl-serine phosphorylation (GO:0018105) 
20150429: root_PTN000683254 participates in intracellular signal transduction (GO:0035556) 
20150429: Opisthokonta_PTN001219863 participates in G1/S transition of mitotic cell cycle (GO:0000082) 
20150429: Opisthokonta_PTN001219863 participates in regulation of organ growth (GO:0046620) 
20150429: Opisthokonta_PTN001219863 participates in positive regulation of apoptotic process (GO:0043065) 
20150429: Opisthokonta_PTN001219863 participates in hippo signaling (GO:0035329) 
20150429: node_PTN000683510 participates in cytoskeleton organization (GO:0007010) 
20150429: Opisthokonta_PTN001220094 participates in negative regulation of protein phosphatase type 2A activity (GO:0034048) 
20150429: Fungi_PTN001220075 participates in positive regulation of septation initiation signaling (GO:0031031) 
20150429: Amniota_PTN001553943 participates in regulation of heart contraction (GO:0008016) 
20150429: Amniota_PTN001553943 participates in cellular calcium ion homeostasis (GO:0006874) 
20150429: Amniota_PTN001553943 participates in regulation of skeletal muscle contraction by calcium ion signaling (GO:0014722) 
20150429: Amniota_PTN001553943 participates in nuclear envelope organization (GO:0006998) 
20150429: Chordata_PTN001219961 participates in regulation of cell growth (GO:0001558) 
20150429: Chordata_PTN001219961 participates in positive regulation of transporter activity (GO:0032411) 
20150429: Chordata_PTN001219961 participates in cellular sodium ion homeostasis (GO:0006883) 
20150429: Chordata_PTN001219961 participates in regulation of apoptotic process (GO:0042981) 
20150429: Chordata_PTN001219961 participates in positive regulation of sodium ion transport (GO:0010765) 
20150429: Chordata_PTN001219961 participates in regulation of cell proliferation (GO:0042127) 
20150429: Euteleostomi_PTN001553825 participates in neuron projection morphogenesis (GO:0048812) 
20150429: Euteleostomi_PTN000683577 does NOT participate in cytoskeleton organization (GO:0007010) 
20150429: Euteleostomi_PTN001220037 does NOT participate in cytoskeleton organization (GO:0007010) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).