# HISTORY 17 Nov 2016: Saved by mfeuerma using Paint 2.22 # molecular_function 20161117: root_PTN000680267 has function protein serine/threonine kinase activity (GO:0004674) 20161117: Opisthokonta_PTN001218266 has function calmodulin-dependent protein kinase activity (GO:0004683) 20161117: Opisthokonta_PTN001218266 has function calmodulin binding (GO:0005516) 20161117: Opisthokonta_PTN002389359 has function calmodulin-dependent protein kinase activity (GO:0004683) 20161117: Opisthokonta_PTN002389359 has function calmodulin binding (GO:0005516) 20161117: Eumetazoa_PTN002389378 has function myosin light chain kinase activity (GO:0004687) 20161117: Eumetazoa_PTN001218105 has function calmodulin-dependent protein kinase activity (GO:0004683) 20161117: Eumetazoa_PTN001218105 has function calmodulin binding (GO:0005516) 20161117: node_PTN001218151 has function calmodulin-dependent protein kinase activity (GO:0004683) 20161117: node_PTN001218151 has function calmodulin binding (GO:0005516) 20161117: Eukaryota_PTN001967005 has function calmodulin-dependent protein kinase activity (GO:0004683) 20161117: Eukaryota_PTN002389784 has function calmodulin-dependent protein kinase activity (GO:0004683) 20161117: Eukaryota_PTN001552730 has function phosphorylase kinase activity (GO:0004689) 20161117: Eukaryota_PTN001552748 has function protein kinase activator activity (GO:0030295) # cellular_component 20161117: root_PTN000680267 is found in intracellular (GO:0005622) 20161117: Opisthokonta_PTN001218266 is found in nucleus (GO:0005634) 20161117: Opisthokonta_PTN001218266 is found in cytoplasm (GO:0005737) 20161117: Fungi_PTN001218297 is found in cytoplasm (GO:0005737) 20161117: Fungi_PTN001218297 is found in cell division site (GO:0032153) 20161117: Eukaryota_PTN001552730 is found in phosphorylase kinase complex (GO:0005964) 20161117: Eukaryota_PTN001552748 is found in cytoplasm (GO:0005737) 20161117: Eukaryota_PTN001552748 is found in nucleus (GO:0005634) 20161117: Euteleostomi_PTN002389709 is found in nucleus (GO:0005634) 20161117: Euteleostomi_PTN002389709 is found in cytoplasm (GO:0005737) 20161117: Amniota_PTN002389667 is found in cytoplasm (GO:0005737) 20161117: Eukaryota_PTN002389571 is found in nucleus (GO:0005634) 20161117: Magnoliophyta_PTN002389551 is found in cytosol (GO:0005829) 20161117: Opisthokonta_PTN002389494 is found in nucleus (GO:0005634) 20161117: Opisthokonta_PTN002389494 is found in cytoplasm (GO:0005737) 20161117: Euteleostomi_PTN000680687 is found in microtubule cytoskeleton (GO:0015630) 20161117: Eukaryota_PTN001966728 is found in cytoplasm (GO:0005737) 20161117: Euteleostomi_PTN000681034 is found in cytoplasm (GO:0005737) 20161117: Amniota_PTN000680773 is found in cytoplasm (GO:0005737) 20161117: Opisthokonta_PTN002389359 is found in cytoplasm (GO:0005737) 20161117: Nematostella vectensis_A7S4Z6 is NOT found in neuron projection (GO:0043005) 20161117: Nematostella vectensis_A7SDU1 is NOT found in neuron projection (GO:0043005) 20161117: Nematostella vectensis_A7STC5 is NOT found in neuron projection (GO:0043005) 20161117: Nematostella vectensis_A7RF52 is NOT found in neuron projection (GO:0043005) 20161117: Nematostella vectensis_A7T0H5 is NOT found in neuron projection (GO:0043005) 20161117: Trichoplax adhaerens_B3S8L8 is NOT found in neuron projection (GO:0043005) 20161117: Trichoplax adhaerens_B3S632 is NOT found in neuron projection (GO:0043005) 20161117: Monosiga brevicollis_A9UZT1 is NOT found in neuron projection (GO:0043005) 20161117: Opisthokonta_PTN002389359 is found in neuron projection (GO:0043005) # biological_process 20161117: root_PTN000680267 participates in protein phosphorylation (GO:0006468) 20161117: Eukaryota_PTN002389790 participates in DNA repair (GO:0006281) 20161117: Eukaryota_PTN002389790 participates in DNA damage checkpoint (GO:0000077) 20161117: Eukaryota_PTN001552730 participates in glycogen metabolic process (GO:0005977) 20161117: Eukaryota_PTN001552748 participates in cell differentiation (GO:0030154) 20161117: Eukaryota_PTN001552748 participates in signal transduction (GO:0007165) 20161117: Trichoplax adhaerens_B3S4Z1 does NOT participate in nervous system development (GO:0007399) 20161117: Bilateria_PTN000680360 participates in nervous system development (GO:0007399) 20161117: Eukaryota_PTN001552748 participates in positive regulation of protein serine/threonine kinase activity (GO:0071902) 20161117: Euteleostomi_PTN002389709 participates in regulation of apoptotic process (GO:0042981) 20161117: Euteleostomi_PTN002389664 participates in regulation of apoptotic process (GO:0042981) 20161117: Eukaryota_PTN002389571 participates in signal transduction in response to DNA damage (GO:0042770) 20161117: Dictyostelium_PTN001218089 does NOT participate in intrinsic apoptotic signaling pathway in response to DNA damage (GO:0008630) 20161117: Dictyostelium_PTN001217895 does NOT participate in intrinsic apoptotic signaling pathway in response to DNA damage (GO:0008630) 20161117: Alveolata_PTN001966668 does NOT participate in intrinsic apoptotic signaling pathway in response to DNA damage (GO:0008630) 20161117: Eukaryota_PTN002389571 participates in DNA damage checkpoint (GO:0000077) 20161117: Eukaryota_PTN002389571 participates in mitotic DNA damage checkpoint (GO:0044773) 20161117: Dictyostelium_PTN001218089 does NOT participate in regulation of apoptotic process (GO:0042981) 20161117: Dictyostelium_PTN001217895 does NOT participate in regulation of apoptotic process (GO:0042981) 20161117: Alveolata_PTN001966668 does NOT participate in regulation of apoptotic process (GO:0042981) 20161117: Eukaryota_PTN002389571 participates in regulation of apoptotic process (GO:0042981) 20161117: Opisthokonta_PTN002389494 participates in signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) 20161117: Opisthokonta_PTN002389494 participates in mitotic G2 DNA damage checkpoint (GO:0007095) 20161117: Euteleostomi_PTN000680687 participates in microtubule cytoskeleton organization (GO:0000226) 20161117: Euteleostomi_PTN000680668 participates in neuron projection morphogenesis (GO:0048812) 20161117: node_PTN001218151 participates in cellular response to oxidative stress (GO:0034599) 20161117: node_PTN001218151 participates in regulation of cell cycle (GO:0051726) 20161117: Euteleostomi_PTN001966580 participates in positive regulation of neuron projection development (GO:0010976) 20161117: Euteleostomi_PTN000681034 participates in regulation of neuron differentiation (GO:0045664) 20161117: Euteleostomi_PTN000680821 participates in heart development (GO:0007507) 20161117: Euteleostomi_PTN000680821 participates in sarcomerogenesis (GO:0048769) 20161117: Euteleostomi_PTN000680821 participates in cardiac myofibril assembly (GO:0055003) 20161117: Amniota_PTN000680773 participates in skeletal muscle cell differentiation (GO:0035914) 20161117: root_PTN000680267 participates in peptidyl-serine phosphorylation (GO:0018105) 20161117: root_PTN000680267 participates in peptidyl-threonine phosphorylation (GO:0018107) 20161117: root_PTN000680267 participates in intracellular signal transduction (GO:0035556) 20161117: Euteleostomi_PTN000680687 participates in neuron differentiation (GO:0030182) 20161117: Opisthokonta_PTN001218266 participates in positive regulation of protein kinase activity (GO:0045860) 20161117: Opisthokonta_PTN002389359 participates in cell differentiation (GO:0030154) 20161117: Trichoplax adhaerens_B3S8L8 does NOT participate in nervous system development (GO:0007399) 20161117: Trichoplax adhaerens_B3S632 does NOT participate in nervous system development (GO:0007399) 20161117: Monosiga brevicollis_A9UZT1 does NOT participate in nervous system development (GO:0007399) 20161117: Opisthokonta_PTN002389359 participates in nervous system development (GO:0007399) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).