# HISTORY 07 May 2016: Updated by: TOUCHUP-v1.18 18 Mar 2016: Updated by: TOUCHUP-v1.14 27 Mar 2016: Updated by: TOUCHUP-v1.15 # molecular_function 20150114: node_PTN000678822 has function protein serine/threonine kinase activity (GO:0004674) 20150114: Bilateria_PTN000757363 has function histone serine kinase activity (GO:0035174) 20150114: Bilateria_PTN000757363 has function AMP-activated protein kinase activity (GO:0004679) 20150116: Opisthokonta_PTN001217330 has function non-membrane spanning protein tyrosine kinase activity (GO:0004715) # cellular_component 20150114: node_PTN000678822 is found in cytoplasm (GO:0005737) 20150114: node_PTN000678822 is found in nucleus (GO:0005634) 20150114: Fungi_PTN001217453 is found in plasma membrane (GO:0005886) 20150116: Opisthokonta_PTN001217363 is found in nucleotide-activated protein kinase complex (GO:0031588) 20150114: Fungi_PTN001217432 is found in cell cortex (GO:0005938) 20150114: Fungi_PTN001217037 is found in cell cortex (GO:0005938) 20150114: Deuterostomia_PTN001217017 is found in centrosome (GO:0005813) # biological_process 20150116: node_PTN000678822 participates in protein phosphorylation (GO:0006468) 20150114: node_PTN000678822 participates in intracellular signal transduction (GO:0035556) 20150114: Dikarya_PTN001217413 participates in cellular cation homeostasis (GO:0030003) 20150114: Fungi_PTN001217453 participates in mitotic cell cycle (GO:0000278) 20150116: Opisthokonta_PTN001217363 participates in negative regulation of TOR signaling (GO:0032007) 20150116: Opisthokonta_PTN001217363 participates in cellular response to glucose starvation (GO:0042149) 20150114: Deuterostomia_PTN001217365 participates in histone-serine phosphorylation (GO:0035404) 20150116: Opisthokonta_PTN001217330 participates in peptidyl-tyrosine phosphorylation (GO:0018108) 20150114: Euteleostomi_PTN001552280 participates in cellular response to glucose starvation (GO:0042149) 20150114: Eumetazoa_PTN001552066 participates in cellular response to hormone stimulus (GO:0032870) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).