# HISTORY 27 Mar 2016: Updated by: TOUCHUP-v1.15 18 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20150519: Eukaryota_PTN001551673 has function RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977) 20150519: Eukaryota_PTN001551673 has function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding (GO:0001228) # cellular_component 20150519: Eukaryota_PTN001551673 is found in nucleus (GO:0005634) # biological_process 20150519: Eukaryota_PTN001551673 participates in regulation of transcription from RNA polymerase II promoter (GO:0006357) 20150519: Bilateria_PTN000677531 participates in animal organ development (GO:0048513) 20150519: Bilateria_PTN000677531 participates in tissue development (GO:0009888) 20150519: Bilateria_PTN000677531 participates in nervous system development (GO:0007399) 20150519: Euteleostomi_PTN000677536 participates in cartilage condensation (GO:0001502) 20150519: Euteleostomi_PTN000677559 participates in digestive system development (GO:0055123) 20150519: Deuterostomia_PTN000677533 does NOT participate in nervous system development (GO:0007399) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).