# HISTORY 27 Mar 2016: Updated by: TOUCHUP-v1.15 18 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20140210: Euteleostomi_PTN000670181 has function prostaglandin-I synthase activity (GO:0008116) 20140210: Euteleostomi_PTN000671282 has function sterol 12-alpha-hydroxylase activity (GO:0008397) # cellular_component # biological_process 20140210: Euteleostomi_PTN000670181 participates in regulation of apoptotic process (GO:0042981) 20140210: Euteleostomi_PTN000670181 participates in prostaglandin biosynthetic process (GO:0001516) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES human ptgis has annotations to varied bp; did not propagate all; not sure which ones are read outs and which ones are true role. # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).