# HISTORY 04 Aug 2016: Updated by: TOUCHUP-v1.21 # molecular_function 20160421: root_PTN001194385 has function ubiquitin-protein transferase activity (GO:0004842) 20160421: root_PTN001194385 has function ubiquitin protein ligase binding (GO:0031625) 20160421: Metazoa_PTN001950535 has function methylated histone binding (GO:0035064) # cellular_component 20160421: root_PTN001194385 is found in cytoplasm (GO:0005737) 20160421: root_PTN001194385 is found in nucleus (GO:0005634) 20160421: root_PTN001194385 is found in ubiquitin ligase complex (GO:0000151) 20160421: Pseudomonas aeruginosa PAO1_Q9HYV6 is NOT found in nucleus (GO:0005634) 20160421: Bacteria _PTN001194380 is NOT found in nucleus (GO:0005634) # biological_process 20160421: Metazoa_PTN001950535 participates in negative regulation of transcription, DNA-templated (GO:0045892) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).