# HISTORY 27 Mar 2016: Updated by: TOUCHUP-v1.15 18 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20150903: Eukaryota_PTN001193267 has function guanyl-nucleotide exchange factor activity (GO:0005085) 20150903: Eukaryota_PTN001193267 has function SNARE binding (GO:0000149) 20150903: Eukaryota_PTN001193267 has function Rab GTPase binding (GO:0017137) # cellular_component 20150903: Eukaryota_PTN001193267 is found in plasma membrane (GO:0005886) 20150903: Eukaryota_PTN001193267 is found in late endosome (GO:0005770) 20150903: Eukaryota_PTN001193267 is found in tubular endosome (GO:0097422) 20150903: Eukaryota_PTN001193267 is found in transport vesicle (GO:0030133) 20150903: Eukaryota_PTN001193267 is found in early endosome (GO:0005769) 20150903: Metazoa_PTN001949385 is found in neuron projection (GO:0043005) # biological_process 20150903: Eukaryota_PTN001193267 participates in retrograde transport, endosome to plasma membrane (GO:1990126) 20150903: Eukaryota_PTN001193267 participates in early endosome to late endosome transport (GO:0045022) 20150903: Eukaryota_PTN001193267 participates in positive regulation of GTPase activity (GO:0043547) 20150903: Metazoa_PTN001949385 participates in neuron projection morphogenesis (GO:0048812) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).