# HISTORY 27 Mar 2016: Updated by: TOUCHUP-v1.15 18 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20151104: Eukaryota_PTN001537955 has function cytoskeletal adaptor activity (GO:0008093) 20151104: Eukaryota_PTN001537955 has function spectrin binding (GO:0030507) # cellular_component 20151104: Eukaryota_PTN001537955 is found in cytoplasm (GO:0005737) 20151104: Chordata_PTN001191122 is found in costamere (GO:0043034) # biological_process 20151110: Eukaryota_PTN001537955 participates in protein targeting to plasma membrane (GO:0072661) 20151110: Euteleostomi_PTN000650720 participates in membrane assembly (GO:0071709) 20151106: Euteleostomi_PTN000650760 participates in regulation of atrial cardiac muscle cell action potential (GO:0098910) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).