# HISTORY
07 May 2016: Updated by: TOUCHUP-v1.18
18 Mar 2016: Updated by: TOUCHUP-v1.14
27 Mar 2016: Updated by: TOUCHUP-v1.15

# molecular_function
20150819: Eukaryota_PTN000371549 has function histone binding (GO:0042393) 
20150819: Eukaryota_PTN000371549 has function transcription cofactor activity (GO:0003712) 
20150819: Eukaryota_PTN000371549 has function RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977) 
20150819: Eukaryota_PTN000371549 has function chromatin binding (GO:0003682) 

# cellular_component
20150819: Eukaryota_PTN000371549 is found in nucleus (GO:0005634) 
20150819: Dikarya_PTN001236278 is found in Rpd3S complex (GO:0032221) 
20150819: Metazoa_PTN001945750 is found in Sin3-type complex (GO:0070822) 
20150819: Euteleostomi_PTN000646203 is found in histone deacetylase complex (GO:0000118) 

# biological_process
20150819: Eukaryota_PTN000371549 participates in regulation of transcription, DNA-templated (GO:0006355) 
20150819: Bilateria_PTN001187210 participates in negative regulation of transcription from RNA polymerase II promoter (GO:0000122) 
20150819: Metazoa_PTN001945750 participates in negative regulation of transcription from RNA polymerase II promoter (GO:0000122) 
20150819: Euteleostomi_PTN001187172 participates in immune response (GO:0006955) 
20150819: Euteleostomi_PTN001187172 participates in positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 
20150819: Euteleostomi_PTN000646203 participates in negative regulation of transcription from RNA polymerase II promoter (GO:0000122) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).