# HISTORY 07 May 2016: Updated by: TOUCHUP-v1.18 18 Mar 2016: Updated by: TOUCHUP-v1.14 27 Mar 2016: Updated by: TOUCHUP-v1.15 # molecular_function 20150820: root_PTN000642960 has function cation-transporting ATPase activity (GO:0019829) 20150820: node_PTN001943383 has function hydrogen-exporting ATPase activity, phosphorylative mechanism (GO:0008553) 20150820: node_PTN000642961 has function copper-transporting ATPase activity (GO:0043682) 20150821: node_PTN001185002 has function copper-exporting ATPase activity (GO:0004008) 20150821: node_PTN000644029 has function cadmium ion transmembrane transporter activity (GO:0015086) 20150821: node_PTN000644029 has function zinc ion transmembrane transporter activity (GO:0005385) 20150821: node_PTN001184736 has function potassium-transporting ATPase activity (GO:0008556) 20150821: node_PTN000643812 has function calcium-transporting ATPase activity (GO:0005388) 20150821: Chordata_PTN001184752 has function PDZ domain binding (GO:0030165) 20150821: node_PTN001184745 has function PDZ domain binding (GO:0030165) 20150821: Eukaryota_PTN000643123 has function sodium:potassium-exchanging ATPase activity (GO:0005391) 20150821: node_PTN001534116 has function hydrogen:potassium-exchanging ATPase activity (GO:0008900) 20150821: Eukaryota_PTN000643382 has function calcium-transporting ATPase activity (GO:0005388) 20150821: Boreoeutheria_PTN000643405 has function calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential (GO:0086039) 20150821: Eukaryota_PTN000643689 has function calcium-transporting ATPase activity (GO:0005388) 20150821: Eukaryota_PTN000643689 has function manganese-transporting ATPase activity (GO:0015410) # cellular_component 20150821: root_PTN000642960 is found in intracellular membrane-bounded organelle (GO:0043231) 20150821: root_PTN000642960 is found in integral component of plasma membrane (GO:0005887) 20150821: Eumetazoa_PTN001185001 is found in trans-Golgi network (GO:0005802) 20150821: Eumetazoa_PTN001185001 is found in perinuclear region of cytoplasm (GO:0048471) 20150821: Opisthokonta_PTN000643383 is found in sarcoplasmic reticulum membrane (GO:0033017) 20150821: Opisthokonta_PTN000643691 is found in Golgi membrane (GO:0000139) 20150821: Eukaryota_PTN001534340 is found in endoplasmic reticulum (GO:0005783) # biological_process 20150821: Eukaryota_PTN000644064 participates in regulation of intracellular pH (GO:0051453) 20150821: Eukaryota_PTN000644064 participates in hydrogen ion transmembrane transport (GO:1902600) 20150821: node_PTN001185002 participates in copper ion export (GO:0060003) 20150821: node_PTN001185002 participates in cellular copper ion homeostasis (GO:0006878) 20150821: Eukaryota_PTN001943819 participates in cellular calcium ion homeostasis (GO:0006874) 20150821: Opisthokonta_PTN000643846 participates in cellular calcium ion homeostasis (GO:0006874) 20150821: Metazoa_PTN001943852 participates in regulation of cytosolic calcium ion concentration (GO:0051480) 20150821: Eukaryota_PTN000643123 participates in ATP hydrolysis coupled proton transport (GO:0015991) 20150821: Eukaryota_PTN000643123 participates in sodium ion export from cell (GO:0036376) 20150821: Eukaryota_PTN000643123 participates in potassium ion import (GO:0010107) 20150821: Eukaryota_PTN000643123 participates in cellular sodium ion homeostasis (GO:0006883) 20150821: Eukaryota_PTN000643123 participates in cellular potassium ion homeostasis (GO:0030007) 20150821: Opisthokonta_PTN000643505 participates in cellular calcium ion homeostasis (GO:0006874) 20150821: Eukaryota_PTN000643319 participates in cellular calcium ion homeostasis (GO:0006874) 20150821: Eukaryota_PTN000643382 participates in cellular calcium ion homeostasis (GO:0006874) 20150821: Boreoeutheria_PTN000643405 participates in regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882) 20150821: Eukaryota_PTN000643689 participates in cellular calcium ion homeostasis (GO:0006874) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES This family contains cation-transporting ATPase. There is a diverse biological processes that these proteins are involved, but most of them seem to be downstream or redundant to MF. This tree will probably require and expert to review it. HM, 21 August 2015 # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).