# HISTORY 07 May 2016: Updated by: TOUCHUP-v1.18 18 Mar 2016: Updated by: TOUCHUP-v1.14 18 Nov 2015: redistribution of PTN001531327 from PTHR24076 to PTHR24078 18 Nov 2015: redistribution of PTN001566394 from PTHR25040 to PTHR24078 27 Mar 2016: Updated by: TOUCHUP-v1.15 # molecular_function # cellular_component 20140815: node_PTN001531278 is found in cytoplasm (GO:0005737) 20140815: Eukaryota_PTN001180323 is found in cytosol (GO:0005829) 20140815: Eukaryota_PTN001531327 is found in cytosol (GO:0005829) 20140815: Eumetazoa_PTN001180543 is found in mitochondrion (GO:0005739) # biological_process 20140827: Embryophyta_PTN001566394 participates in response to ethylene (GO:0009723) 20140815: Eumetazoa_PTN001180543 participates in regulation of apoptotic process (GO:0042981) 20140815: Eumetazoa_PTN001180543 participates in mitochondrion organization (GO:0007005) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES MAF: Large scale mitochondrial membrane lovcation in Yeast have too many false positives to be trusted. Apart from "refolding" (propagated to the root thanks to ECOLI._dnaJ), no other clear exp evidences. Even location is difficult to propagate in such a tree. # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).