# HISTORY 12 Jan 2017: Saved by mfeuerma using Paint 2.28 on 12 Jan 2017 using PANTHER version UPL 11.0 # molecular_function 20170112: Eumetazoa_PTN001171982 has function JUN kinase activity (GO:0004705) 20170112: Eukaryota_PTN002372889 has function MAP kinase activity (GO:0004707) 20170112: Eukaryota_PTN000622871 has function MAP kinase activity (GO:0004707) 20170112: Eukaryota_PTN000622282 has function MAP kinase activity (GO:0004707) 20170112: Eukaryota_PTN000622192 has function protein serine/threonine kinase activity (GO:0004674) 20170112: Eukaryota_PTN001934972 has function protein serine/threonine kinase activity (GO:0004674) 20170112: Eukaryota_PTN001934972 has function MAP kinase activity (GO:0004707) 20170112: Eukaryota_PTN000622130 has function protein serine/threonine kinase activity (GO:0004674) 20170112: Eukaryota_PTN001935377 has function MAP kinase activity (GO:0004707) 20170112: Eukaryota_PTN000622883 has function protein serine/threonine kinase activity (GO:0004674) # cellular_component 20170112: root_PTN000622075 is found in nucleus (GO:0005634) 20170112: root_PTN000622075 is found in cytoplasm (GO:0005737) 20170112: Bilateria_PTN000622286 is found in neuron projection (GO:0043005) 20170112: node_PTN002372930 is found in late endosome (GO:0005770) 20170112: node_PTN002372930 is found in caveola (GO:0005901) 20170112: node_PTN002372930 is found in focal adhesion (GO:0005925) 20170112: node_PTN002372930 is found in cytoskeleton (GO:0005856) 20170112: node_PTN002372930 is found in early endosome (GO:0005769) 20170112: node_PTN002372930 is found in Golgi apparatus (GO:0005794) 20170112: node_PTN002372930 is found in mitochondrion (GO:0005739) 20170112: node_PTN002372930 is found in cytosol (GO:0005829) 20170112: Opisthokonta_PTN001172286 is found in cilium (GO:0005929) # biological_process 20170112: Eumetazoa_PTN001171982 participates in JNK cascade (GO:0007254) 20170112: Bilateria_PTN000622286 participates in neuron development (GO:0048666) 20170112: Euteleostomi_PTN000622311 participates in positive regulation of apoptotic process (GO:0043065) 20170112: Euteleostomi_PTN000622311 participates in response to mechanical stimulus (GO:0009612) 20170112: Euteleostomi_PTN000622311 participates in response to organic substance (GO:0010033) 20170112: Eukaryota_PTN000622883 participates in regulation of mRNA processing (GO:0050684) 20170112: Eukaryota_PTN001935377 participates in positive regulation of sequence-specific DNA binding transcription factor activity (GO:0051091) 20170112: Eukaryota_PTN001935377 participates in response to osmotic stress (GO:0006970) 20170112: Eukaryota_PTN001935377 participates in cellular response to osmotic stress (GO:0071470) 20170112: Eukaryota_PTN000622883 participates in intracellular signal transduction (GO:0035556) 20170112: Fungi_PTN001172219 participates in regulation of protein localization to nucleus (GO:1900180) 20170112: Eukaryota_PTN000622883 participates in spliceosomal complex assembly (GO:0000245) 20170112: Eukaryota_PTN000622130 participates in signal transduction (GO:0007165) 20170112: root_PTN000622075 participates in intracellular signal transduction (GO:0035556) 20170112: Opisthokonta_PTN001172286 participates in cilium assembly (GO:0060271) 20170112: Opisthokonta_PTN001172286 participates in intraciliary transport (GO:0042073) 20170112: Eumetazoa_PTN001171853 participates in cell surface receptor signaling pathway (GO:0007166) 20170112: Eumetazoa_PTN001171853 participates in cellular response to organic substance (GO:0071310) 20170112: Eukaryota_PTN000622282 participates in cellular response to organic substance (GO:0071310) 20170112: Fungi_PTN001172058 participates in stress-activated MAPK cascade (GO:0051403) 20170112: node_PTN002372936 participates in G-protein coupled receptor signaling pathway (GO:0007186) 20170112: Fungi_PTN001172058 participates in osmosensory signaling pathway (GO:0007231) 20170112: Dikarya_PTN001172087 participates in pheromone-dependent signal transduction involved in conjugation with cellular fusion (GO:0000750) 20170112: Fungi_PTN001172058 participates in cellular response to oxidative stress (GO:0034599) 20170112: Dikarya_PTN001172087 participates in sexual sporulation resulting in formation of a cellular spore (GO:0043935) 20170112: Eukaryota_PTN000622282 participates in regulation of gene expression (GO:0010468) 20170112: root_PTN000622075 participates in regulation of gene expression (GO:0010468) 20170112: Euteleostomi_PTN000622311 participates in cellular response to organic substance (GO:0071310) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).