# HISTORY
07 May 2016: Updated by: TOUCHUP-v1.18
17 Mar 2016: Updated by: TOUCHUP-v1.14
27 Mar 2016: Updated by: TOUCHUP-v1.15

# molecular_function
20150709: root_PTN000596745 has function RNA binding (GO:0003723) 
20150709: Eukaryota_PTN000596817 has function U6 snRNA binding (GO:0017070) 

# cellular_component
20150709: Eukaryota_PTN000596746 is found in U5 snRNP (GO:0005682) 
20150709: Eukaryota_PTN000596746 is found in U4 snRNP (GO:0005687) 
20150709: Eukaryota_PTN000596746 is found in SMN-Sm protein complex (GO:0034719) 
20150709: Eukaryota_PTN000596746 is found in U2 snRNP (GO:0005686) 
20150709: Eukaryota_PTN000596746 is found in precatalytic spliceosome (GO:0071011) 
20150709: Eukaryota_PTN000596746 is found in U1 snRNP (GO:0005685) 
20150709: Eukaryota_PTN000596746 is found in spliceosomal tri-snRNP complex (GO:0097526) 
20150709: Eukaryota_PTN000596746 is found in U12-type spliceosomal complex (GO:0005689) 
20150709: Eukaryota_PTN000596746 is found in prespliceosome (GO:0071010) 
20150709: Eukaryota_PTN000596746 is found in commitment complex (GO:0000243) 
20150709: Eukaryota_PTN000596746 is found in pICln-Sm protein complex (GO:0034715) 
20150709: Eukaryota_PTN000596746 is found in catalytic step 2 spliceosome (GO:0071013) 
20150709: Eukaryota_PTN000596880 is found in U12-type spliceosomal complex (GO:0005689) 
20150709: Eukaryota_PTN000596880 is found in SMN-Sm protein complex (GO:0034719) 
20150709: Eukaryota_PTN000596880 is found in U2 snRNP (GO:0005686) 
20150709: Eukaryota_PTN000596880 is found in precatalytic spliceosome (GO:0071011) 
20150709: Eukaryota_PTN000596880 is found in U4 snRNP (GO:0005687) 
20150709: Eukaryota_PTN000596880 is found in spliceosomal tri-snRNP complex (GO:0097526) 
20150709: Eukaryota_PTN000596880 is found in catalytic step 2 spliceosome (GO:0071013) 
20150709: Eukaryota_PTN000596880 is found in pICln-Sm protein complex (GO:0034715) 
20150709: Eukaryota_PTN000596880 is found in U1 snRNP (GO:0005685) 
20150709: Eukaryota_PTN000596880 is found in commitment complex (GO:0000243) 
20150709: Eukaryota_PTN000596880 is found in prespliceosome (GO:0071010) 
20150709: Eukaryota_PTN000596880 is found in U5 snRNP (GO:0005682) 
20150709: Eukaryota_PTN000596817 is found in U6 snRNP (GO:0005688) 
20150709: Eukaryota_PTN000596817 is found in cytoplasmic mRNA processing body (GO:0000932) 
20150709: Eukaryota_PTN000596817 is found in spliceosomal tri-snRNP complex (GO:0097526) 

# biological_process
20150709: root_PTN000596745 participates in spliceosomal complex assembly (GO:0000245) 
20150709: root_PTN000596745 participates in spliceosomal snRNP assembly (GO:0000387) 
20150709: Eukaryota_PTN000596817 participates in nuclear-transcribed mRNA catabolic process (GO:0000956) 
20150709: Eukaryota_PTN000596817 participates in cytoplasmic mRNA processing body assembly (GO:0033962) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
This family contains Sm and Like Sm (Lsm) proteins, with three subclades:
- Eukaryota_PTN000596746 = SMD1, SNRPD1
- Eukaryota_PTN000596880 = SMD3, SNRPD3
- Eukaryota_PTN000596817 = LSM4
This family contains two members of the highly conserved core Sm proteins:
- Sm D1 (encoded by SMD1 in S. cerevisiae and SNRPD1 in vertebrates)
- Sm D3 (encoded by SMD3 in S. cerevisiae and SNRPD3 in vertebrates)
The Sm proteins are part of heteroheptameric complex (composed of Smb1, Smd1, Smd2, Smd3, Sme1, Smx3, and Smx2) that are essential components of the spliceosomal U1, U2, U4, and U5 snRNPs.
This family contains the highly conserved Lsm4 protein.
The Lsm proteins 1-8 are found in two seven membered Lsm rings, each containing Lsm2-7, and containing either Lsm1 or Lsm8. The complex containing Lsm8 localizes to the nucleus where it binds the U6 snRNA and is involved in spliceosomal splicing. The complex containing Lsm1 is cytoplasmic where it associates with he Pat1p decapping enzyme and Xrn1p exoribonucleases and is involved in mRNA degradation.

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).