# HISTORY 27 Mar 2016: Updated by: TOUCHUP-v1.15 17 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20150424: Bilateria_PTN000589024 has function receptor binding (GO:0005102) 20150424: Bilateria_PTN000589024 has function protein homodimerization activity (GO:0042803) 20150424: Bilateria_PTN000589024 has function cell adhesion molecule binding (GO:0050839) 20150424: Bilateria_PTN000589024 has function receptor activity (GO:0004872) # cellular_component 20150424: Bilateria_PTN000589024 is found in integral component of plasma membrane (GO:0005887) 20150424: Bilateria_PTN000589024 is found in cell-cell adherens junction (GO:0005913) # biological_process 20150424: Bilateria_PTN000589024 participates in cell recognition (GO:0008037) 20150424: Bilateria_PTN000589024 participates in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157) 20150424: Bilateria_PTN000589024 participates in homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156) 20150424: Euteleostomi_PTN000589343 participates in susceptibility to natural killer cell mediated cytotoxicity (GO:0042271) 20150424: Theria _PTN000589176 participates in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target (GO:0002860) 20150424: Theria _PTN000589176 participates in susceptibility to T cell mediated cytotoxicity (GO:0060370) 20150424: Theria _PTN000589176 participates in susceptibility to natural killer cell mediated cytotoxicity (GO:0042271) 20150424: Euteleostomi_PTN001150323 participates in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target (GO:0002860) 20150424: Euteleostomi_PTN001512560 participates in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target (GO:0002860) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).