# HISTORY 07 May 2016: Updated by: TOUCHUP-v1.18 17 Mar 2016: Updated by: TOUCHUP-v1.14 27 Mar 2016: Updated by: TOUCHUP-v1.15 # molecular_function 20150511: root_PTN001149889 has function ATP-dependent 5'-3' DNA helicase activity (GO:0043141) 20150511: cellular organisms_PTN001512181 has function telomerase inhibitor activity (GO:0010521) # cellular_component 20150511: root_PTN001149889 is found in replication fork (GO:0005657) 20150511: cellular organisms_PTN001512181 is found in mitochondrion (GO:0005739) 20150511: cellular organisms_PTN001512181 is found in nucleus (GO:0005634) # biological_process 20150511: root_PTN001149889 participates in DNA replication (GO:0006260) 20150511: root_PTN001149889 participates in DNA duplex unwinding (GO:0032508) 20150511: cellular organisms_PTN001512181 participates in negative regulation of telomerase activity (GO:0051974) 20150511: cellular organisms_PTN001512181 participates in negative regulation of telomere maintenance via telomerase (GO:0032211) 20150511: cellular organisms_PTN001512181 participates in mitochondrial genome maintenance (GO:0000002) 20150511: cellular organisms_PTN001512181 participates in G-quadruplex DNA unwinding (GO:0044806) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES Annotated PG 2015-05-11 # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).