# HISTORY
26 Mar 2016: Updated by: TOUCHUP-v1.15
17 Mar 2016: Updated by: TOUCHUP-v1.14

# molecular_function
20140728: root_PTN000568211 has function oxoglutarate dehydrogenase (succinyl-transferring) activity (GO:0004591) 

# cellular_component
20140728: root_PTN000568211 is found in cytosol (GO:0005829) 
20140728: root_PTN000568211 is found in oxoglutarate dehydrogenase complex (GO:0045252) 
20140728: Eukaryota_PTN000568260 is found in mitochondrion (GO:0005739) 
20140728: Eukaryota_PTN000568214 is found in mitochondrion (GO:0005739) 
20140728: Eukaryota_PTN001140017 is NOT found in cytosol (GO:0005829) 
20140728: Eukaryota_PTN000568260 is NOT found in cytosol (GO:0005829) 

# biological_process
20140728: root_PTN000568211 participates in tricarboxylic acid cycle (GO:0006099) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
MF: This is an interesting case where horizontal gene transfer has occurred. Although one copy of the gene doesn't have experimental evidence, the oxoglutarate dehydrogenase activity was propagated to the root because strong sequence alignment and the Process annotation for the Human gene was consistent with the role this gene product functions in.
CC: The oxoglutarate dehydrogenase complex was propagated to the root because the ancestor performed this function as part of the complex. The bacterial proteins were part of the cytosol while the eukaryotes are part of the mitochondrion.
BP: The TCA cycle is well conserved and hence propageted to the root node.

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).