# HISTORY 07 May 2016: Updated by: TOUCHUP-v1.18 17 Mar 2016: Updated by: TOUCHUP-v1.14 26 Mar 2016: Updated by: TOUCHUP-v1.15 # molecular_function 20150908: node_PTN000753849 has function tumor necrosis factor-activated receptor activity (GO:0005031) 20150909: Euteleostomi_PTN000559309 has function nerve growth factor binding (GO:0048406) 20150909: Amniota_PTN000559073 has function tumor necrosis factor binding (GO:0043120) # cellular_component 20150908: node_PTN000753849 is found in integral component of plasma membrane (GO:0005887) 20150909: Euteleostomi_PTN000559309 is found in neuron projection (GO:0043005) 20150909: Euteleostomi_PTN000559309 is found in nucleus (GO:0005634) 20150909: Euteleostomi_PTN001895566 is found in nucleus (GO:0005634) 20150909: Euteleostomi_PTN001895566 is found in neuron projection (GO:0043005) 20150908: Amniota_PTN000559073 is found in mitochondrion (GO:0005739) # biological_process 20150909: node_PTN000753849 participates in inflammatory response (GO:0006954) 20150909: node_PTN000753849 participates in regulation of cell proliferation (GO:0042127) 20150909: node_PTN000753849 participates in regulation of apoptotic process (GO:0042981) 20150909: node_PTN000753849 participates in apoptotic signaling pathway (GO:0097190) 20150909: node_PTN000753849 participates in multicellular organism development (GO:0007275) 20150909: node_PTN000753849 participates in immune response (GO:0006955) 20150909: node_PTN000753849 participates in response to lipopolysaccharide (GO:0032496) 20150909: node_PTN001499622 participates in positive regulation of MAPK cascade (GO:0043410) 20150909: Euteleostomi_PTN000559309 participates in negative regulation of neuron projection development (GO:0010977) 20150909: Euteleostomi_PTN000559309 participates in axon guidance (GO:0007411) 20150909: Euteleostomi_PTN001895566 participates in regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043281) 20150909: Euteleostomi_PTN001895566 participates in extrinsic apoptotic signaling pathway via death domain receptors (GO:0008625) 20150909: Euteleostomi_PTN001895566 participates in brain development (GO:0007420) 20150909: Amniota_PTN000559164 participates in negative regulation of myelination (GO:0031642) 20150909: Amniota_PTN000559164 participates in regulation of oligodendrocyte differentiation (GO:0048713) 20150909: node_PTN001895623 participates in extrinsic apoptotic signaling pathway via death domain receptors (GO:0008625) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).