# HISTORY
26 Mar 2016: Updated by: TOUCHUP-v1.15
17 Mar 2016: Updated by: TOUCHUP-v1.14
17 Mar 2016: Updated by: TOUCHUP-v1.14

# molecular_function

# cellular_component
20151118: Eukaryota_PTN001886630 is found in nuclear pore (GO:0005643) 

# biological_process
# PRUNED

26 Mar 2016: node_PTN001886646 has been pruned from tree

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
17 Mar 2016: node_PTN001886646 has been pruned from tree
17 Mar 2016: node_PTN001886646 has been pruned from tree
This family comprises the NUP210 (aka Gp210), a POM, which is an integral membrane protein of the nuclear envelope membrane domain of the nuclear pore complex. NUP210 is present in vertebrates and many other eukaryotes including plants, but not in S. cerevisiae and other yeast [Hoelz et al. 2011 (PMID:21495847), Aitchison and Rout 2012 (PMID:22419078), and Kabachinski and Schwartz 2015 (PMID:26046137)].
Comment on pruned sequences:
--------------------------
Two Yersinia pestis sequences were attached to most of the rest of the tree through a horizontal transfer node, and a Vitis vinifera sequence was attached as an outgroup with a really long branch length above the horizontal transfer node. There was a short section of sequence for these three sequences that showed a small amount of alignment with the most conserved residues of a region of the N-terminus NUP210 sequences. However, these three sequences were much shorter than the NUP210 sequences and overall did not look like they belonged in this family.

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).