# HISTORY 04 Aug 2016: Updated by: TOUCHUP-v1.21 # molecular_function 20160502: Eukaryota_PTN000541279 has function double-stranded DNA binding (GO:0003690) 20160502: Eukaryota_PTN000541279 has function chromatin binding (GO:0003682) 20160502: Boreoeutheria_PTN001122421 has function neuropeptide hormone activity (GO:0005184) 20160502: Boreoeutheria_PTN001122421 has function G-protein coupled receptor binding (GO:0001664) 20160502: Boreoeutheria_PTN001122421 has LOST/MODIFIED function double-stranded DNA binding (GO:0003690) 20160502: Boreoeutheria_PTN001122421 has LOST/MODIFIED function chromatin binding (GO:0003682) # cellular_component 20160502: Eukaryota_PTN000541279 is found in Fanconi anaemia nuclear complex (GO:0043240) 20160502: Eukaryota_PTN000541279 is found in FANCM-MHF complex (GO:0071821) 20160502: Boreoeutheria_PTN001122421 is NOT found in Fanconi anaemia nuclear complex (GO:0043240) 20160502: Boreoeutheria_PTN001122421 is NOT found in FANCM-MHF complex (GO:0071821) # biological_process 20160502: Eukaryota_PTN000541279 participates in interstrand cross-link repair (GO:0036297) 20160502: Eukaryota_PTN000541279 participates in replication fork processing (GO:0031297) 20160502: Eukaryota_PTN000541279 participates in resolution of meiotic recombination intermediates (GO:0000712) 20160502: Eukaryota_PTN000541279 participates in mitotic recombination (GO:0006312) 20160502: Boreoeutheria_PTN001122421 participates in adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway (GO:0007193) 20160502: Boreoeutheria_PTN001122421 does NOT participate in interstrand cross-link repair (GO:0036297) 20160502: Boreoeutheria_PTN001122421 does NOT participate in replication fork processing (GO:0031297) 20160502: Boreoeutheria_PTN001122421 does NOT participate in resolution of meiotic recombination intermediates (GO:0000712) 20160502: Boreoeutheria_PTN001122421 does NOT participate in mitotic recombination (GO:0006312) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).