# HISTORY 18 Oct 2016: Saved by krc using Paint 2.25 17 Mar 2016: Updated by: TOUCHUP-v1.14 26 Mar 2016: Updated by: TOUCHUP-v1.15 # molecular_function 20161018: Eukaryota_PTN001482552 has function RNA binding (GO:0003723) 20161018: Eukaryota_PTN000356711 has function ubiquitin-protein transferase activity (GO:0004842) # cellular_component 20161018: Eukaryota_PTN000356653 is found in Pwp2p-containing subcomplex of 90S preribosome (GO:0034388) 20161018: Eukaryota_PTN000356653 is found in small-subunit processome (GO:0032040) 20161018: Eukaryota_PTN000356711 is found in U2-type catalytic step 1 spliceosome (GO:0071006) 20161018: Eukaryota_PTN000356711 is found in Prp19 complex (GO:0000974) # biological_process 20161018: Eukaryota_PTN000356653 participates in rRNA processing (GO:0006364) 20161018: Eukaryota_PTN002336300 participates in ribosomal large subunit biogenesis (GO:0042273) 20161018: Eukaryota_PTN002336300 participates in rRNA processing (GO:0006364) 20161018: Eukaryota_PTN000356711 participates in generation of catalytic spliceosome for first transesterification step (GO:0000349) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED ## Annotations that have been removed. 20141113: Eukaryota_PTN000520141 to ribosomal large subunit biogenesis (GO:0042273) using [SGD:S000006373] - lacks supporting evidence # NOTES NOTE: NOT "spliceosome" annotations for mouse Prpf19 are specifically for the beta isoform (Q99KP6-2). The canonical isoform Q99KP6-1 IS part of the spliceosome. # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).