# HISTORY 28 Oct 2016: Saved by pgaudet using Paint 2.25 # molecular_function 20161028: node_PTN000512260 has function structural constituent of myelin sheath (GO:0019911) # cellular_component 20161028: Eumetazoa_PTN001103553 is found in integral component of membrane (GO:0016021) 20161028: Bilateria_PTN000512256 is found in membrane raft (GO:0045121) 20161028: Euteleostomi_PTN000512431 is found in endoplasmic reticulum membrane (GO:0005789) # biological_process 20161028: node_PTN000512260 participates in myelination (GO:0042552) 20161028: Bilateria_PTN000512256 participates in membrane raft polarization (GO:0001766) 20161028: Bilateria_PTN000512256 participates in protein localization (GO:0008104) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).