# HISTORY
07 May 2016: Updated by: TOUCHUP-v1.18
17 Mar 2016: Updated by: TOUCHUP-v1.14
26 Mar 2016: Updated by: TOUCHUP-v1.15

# molecular_function
20140527: node_PTN000507731 has function double-stranded DNA 3'-5' exodeoxyribonuclease activity (GO:0008311) 
20140527: node_PTN000507731 has function DNA-(apurinic or apyrimidinic site) lyase activity (GO:0003906) 

# cellular_component
20140527: cellular organisms_PTN000507732 is found in nucleus (GO:0005634) 
20140527: Archaea_PTN000507850 is NOT found in nucleus (GO:0005634) 

# biological_process
20140527: node_PTN000507731 participates in base-excision repair (GO:0006284) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
E coli xthA is annoated as an exonuclease (PMID 342234). Page 322 of the reference includes the following: xthA mutants lose simultaneously the main endonuclease for apurinic sites and exonuclease III. It is likely that xthA have both AP endonuclease and exonuclease activity but the former annotation is currently missing. The curator propagated the 'AP lyase activity (GO:0003906) to the root.

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).