# HISTORY 26 Mar 2016: Updated by: TOUCHUP-v1.15 17 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20150911: root_PTN000492974 has function transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer (GO:0046912) 20150911: node_PTN000492975 has function malate synthase activity (GO:0004474) 20150911: Bacteria _PTN001855076 has function methylisocitrate lyase activity (GO:0046421) 20150911: node_PTN001091980 has function malate synthase activity (GO:0004474) 20150911: node_PTN000493043 has function isocitrate lyase activity (GO:0004451) 20150911: Dikarya_PTN001091853 has function methylisocitrate lyase activity (GO:0046421) 20150911: Dikarya_PTN001091853 has LOST/MODIFIED function isocitrate lyase activity (GO:0004451) # cellular_component 20150911: root_PTN000492974 is found in cytoplasm (GO:0005737) 20150911: node_PTN001091980 is found in cytosol (GO:0005829) 20150911: Dikarya_PTN001091853 is found in mitochondrial matrix (GO:0005759) 20150911: Viridiplantae_PTN000493068 is found in glyoxysome (GO:0009514) # biological_process 20150911: root_PTN000492974 participates in glyoxylate cycle (GO:0006097) 20150911: Bacteria _PTN001855076 participates in propionate catabolic process, 2-methylcitrate cycle (GO:0019629) 20150911: Dikarya_PTN001091853 participates in propionate catabolic process, 2-methylcitrate cycle (GO:0019629) 20150911: Dikarya_PTN001091853 does NOT participate in glyoxylate cycle (GO:0006097) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).