# HISTORY 26 Mar 2016: Updated by: TOUCHUP-v1.15 16 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function # cellular_component 20140709: Eukaryota_PTN000468090 is found in cilium (GO:0005929) 20140709: Eukaryota_PTN000468090 is found in intraciliary transport particle B (GO:0030992) # biological_process 20140709: Eukaryota_PTN000468090 participates in intraciliary transport (GO:0042073) 20140709: Eukaryota_PTN000468090 participates in cilium assembly (GO:0042384) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES This family contains IFT70, a subunit of the intraciliary transport complex IFT B. This protein is known by various names depending on the species, and doesn't yet have nomenclature which used consistently across the majority of the species where it is found. In C. elegans, it is called dyf-1; in Zebrafish, it is called fleer (or flr); in mammals, where it has undergone numerous duplications such that many species have 2 or even 3 copies, it is called TTC30B, while the duplicated copy/copies have names like TTC30A or Ttc30a1 and Ttc30a2. The IFT B complex is found in all types of cilia, both primary cilia (motile and non-motile) and motile cilia (including sperm flagella) and is involved in intraciliary anterograde transport (from the base to the tip) within the cilium (PMID:19253336, PMID:19450523, PMID:23945166). Annotation comments ----------------- I am not propagating any MF annotations. The annotation to "tubulin-glycine ligase activity" (GO:0070738) doesn't seem justified looking at the paper (PMID:21262966). The two papers (PMID:16049494 and PMID:17761526) that are the source of annotations to "transporter activity" (GO:0005215) don't seem to provide any information about how a TTC30 protein functions, only that it is involved in the process of intraciliary transport, so I am reluctant to make an MF annotation. # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).