# HISTORY 30 Nov 2016: Saved by krc using Paint 2.28.1 on 30 Nov 2016 using PANTHER version UPL 11.0 16 Jun 2016: Saved by krc using Paint 2.0-beta19 # molecular_function 20160616: root_PTN000466551 has function ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process (GO:0000036) 20160616: root_PTN000466551 has function acyl binding (GO:0000035) 20160616: root_PTN000466551 has function phosphopantetheine binding (GO:0031177) 20160616: Eukaryota_PTN000466553 has LOST/MODIFIED function ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process (GO:0000036) 20160616: Eukaryota_PTN000466553 has LOST/MODIFIED function phosphopantetheine binding (GO:0031177) 20160616: Eukaryota_PTN000466553 has LOST/MODIFIED function acyl binding (GO:0000035) 20161130: Eukaryota_PTN000466553 has function ribosomal large subunit binding (GO:0043023) # cellular_component 20160616: root_PTN000466551 is found in cytosol (GO:0005829) 20160616: Eukaryota_PTN000466553 is NOT found in cytosol (GO:0005829) 20161130: Eukaryota_PTN000466553 is found in preribosome, large subunit precursor (GO:0030687) # biological_process 20160616: root_PTN000466551 participates in lipid A biosynthetic process (GO:0009245) 20161130: Eukaryota_PTN000466553 participates in ribosomal large subunit export from nucleus (GO:0000055) 20160616: Eukaryota_PTN000466553 does NOT participate in lipid A biosynthetic process (GO:0009245) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES I think that the BUD20 (aka ZNF593) clade is inappropriately placed in this tree. When viewing the tree, the root of this clade (9EUKA:PTN000466553) has a very long branch length compared to all of the others. In addition, the MSA of the whole family does not look very good. However, when the BUD20 clade is collapsed at its root (9EUKA:PTN000466553), the MSA of the other three branches looks quite good even all the way the the bacterial clade (9BACT:PTN000466714). I have annotated the BUD20 clade anyway since it was the reason I was doing this family. # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).