# HISTORY
26 Mar 2016: Updated by: TOUCHUP-v1.15
16 Mar 2016: Updated by: TOUCHUP-v1.14

# molecular_function
20121213: Eukaryota_PTN000455350 has function fructokinase activity (GO:0008865) 
20121213: Eukaryota_PTN000455350 has function glucokinase activity (GO:0004340) 
20121213: Eukaryota_PTN000455350 has function mannokinase activity (GO:0019158) 
20121213: Euteleostomi_PTN000455410 has LOST/MODIFIED function fructokinase activity (GO:0008865) 
20121213: Euteleostomi_PTN000455410 has LOST/MODIFIED function mannokinase activity (GO:0019158) 

# cellular_component
20121213: Eukaryota_PTN000455350 is found in cytosol (GO:0005829) 

# biological_process
20121213: Eukaryota_PTN000455350 participates in cellular glucose homeostasis (GO:0001678) 
20121213: Eukaryota_PTN000455350 participates in glycolytic process (GO:0006096) 
20121213: Euteleostomi_PTN000455410 participates in regulation of insulin secretion (GO:0050796) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
Ignore outgroup bacterial sequence, probable horizontal transfer.  Bacteria carry out this function using a nonhomologous enzyme.  No annotations will be made prior to eukaryotic root.
Wikipedia is useful: vertebrate hexokinases have broad specificity (glucose, fructose, mannose), except for glucokinase.  Glucokinase also acts as a glucose sensor for insulin secretion in vertebrates.
MF:
Propagate gluco-, fructo- and mannokinase activities to eukaryotic root, due to experimental annotations in vertebrate paralogs and relatives in S. pombe.  Annotate loss of fructo- and mannokinase activities in vertebrate glucokinase clade.
CC:
Propagate cytosol to eukaryotic root because this is where the enzyme is active in glycolysis.  It is shuttled to the nucleus to inhibit its activity, so do not propagate this term.
BP:
Propagate glycolysis, cellular glucose homeostasis (should be a parent of glycolysis) to eukaryotic root.  Propagate regulation of insulin secretion to vertebrate glucokinase ancestor.  Other processes are either molecular processes, or too indirect.
All annotations are inferred to have been lost in the yeast YLR446W clade, as this gene has not been shown to be a hexokinase, and some members of the clade are lacking a conserved tryptophan (at position 257 in human glucokinase that almost completely inactivates the enzyme).  Use IRD instead of IKR because not certain of effect on activity.
PAINT annotation team, 12 December 2012

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).