# HISTORY 07 May 2016: Updated by: TOUCHUP-v1.18 16 Mar 2016: Updated by: TOUCHUP-v1.14 26 Mar 2016: Updated by: TOUCHUP-v1.15 # molecular_function 20150909: root_PTN000443108 has function ATPase activity, coupled to transmembrane movement of substances (GO:0042626) 20150909: Fungi_PTN001059723 has function xenobiotic-transporting ATPase activity (GO:0008559) 20150909: Eumetazoa_PTN001059382 has function sterol-transporting ATPase activity (GO:0034041) 20150909: Eumetazoa_PTN001059382 has function cholesterol transporter activity (GO:0017127) 20150909: Eukaryota_PTN001059245 has function drug transmembrane transporter activity (GO:0015238) 20150909: Eukaryota_PTN001829432 contributes to function cholesterol transporter activity (GO:0017127) 20150909: Magnoliophyta_PTN001829566 has function fatty acid transporter activity (GO:0015245) # cellular_component 20150909: root_PTN000443108 is found in plasma membrane (GO:0005886) 20150909: root_PTN000443108 is found in integral component of membrane (GO:0016021) 20150909: saccharomyceta_PTN001059725 is found in fungal-type vacuole membrane (GO:0000329) 20150909: Eukaryota_PTN001829432 is found in receptor complex (GO:0043235) 20150909: Eukaryota_PTN001829432 is found in apical plasma membrane (GO:0016324) 20150909: saccharomyceta_PTN001059725 is NOT found in plasma membrane (GO:0005886) # biological_process 20150909: Fungi_PTN001059723 participates in cellular response to drug (GO:0035690) 20150909: saccharomyceta_PTN001453266 participates in sterol import (GO:0035376) 20150909: Chordata_PTN001059392 participates in cholesterol efflux (GO:0033344) 20150909: Eumetazoa_PTN001059419 participates in ommochrome biosynthetic process (GO:0006727) 20150909: node_PTN000443222 participates in eye pigment precursor transport (GO:0006856) 20150909: node_PTN000751237 participates in culmination involved in sorocarp development (GO:0031154) 20150909: node_PTN000751237 participates in sorocarp morphogenesis (GO:0031288) 20150909: node_PTN000751237 participates in aggregation involved in sorocarp development (GO:0031152) 20150909: Eumetazoa_PTN001059255 participates in drug transmembrane transport (GO:0006855) 20150909: node_PTN001059293 participates in aggregation involved in sorocarp development (GO:0031152) 20150909: node_PTN001059293 participates in sorocarp morphogenesis (GO:0031288) 20150909: Eukaryota_PTN001829432 participates in cholesterol efflux (GO:0033344) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).