# HISTORY 09 Jul 2016: Updated by: TOUCHUP-v1.19 # molecular_function 20160428: Eukaryota_PTN001038805 has function superoxide-generating NADPH oxidase activator activity (GO:0016176) 20160428: Eukaryota_PTN001038805 has function phosphatidylinositol binding (GO:0035091) 20160428: Chordata_PTN001437869 has function phosphatidylinositol-3,4-bisphosphate binding (GO:0043325) 20160428: Euteleostomi_PTN000403589 has function phosphatidylinositol-3,5-bisphosphate binding (GO:0080025) 20160428: Euteleostomi_PTN000403589 has function phosphatidylinositol-3-phosphate binding (GO:0032266) 20160428: Euteleostomi_PTN000403589 has function phosphatidylinositol-4-phosphate binding (GO:0070273) 20160428: Euteleostomi_PTN000403589 has function phosphatidylinositol-5-phosphate binding (GO:0010314) # cellular_component 20160428: Eukaryota_PTN001038805 is found in intracellular (GO:0005622) 20160428: Chordata_PTN001437869 is found in NADPH oxidase complex (GO:0043020) 20160428: Chordata_PTN001437869 is found in cytosol (GO:0005829) 20160428: Chordata_PTN001812816 is found in NADPH oxidase complex (GO:0043020) 20160428: Chordata_PTN001038814 is found in podosome (GO:0002102) # biological_process 20160428: Eukaryota_PTN001038805 participates in superoxide metabolic process (GO:0006801) 20160428: Eukaryota_PTN001038805 participates in oxidation-reduction process (GO:0055114) 20160428: Chordata_PTN001437869 participates in respiratory burst (GO:0045730) 20160428: Chordata_PTN001038814 participates in podosome assembly (GO:0071800) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).