# HISTORY 25 Mar 2016: Updated by: TOUCHUP-v1.15 15 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20150813: Eukaryota_PTN000335993 has function uniporter activity (GO:0015292) 20150813: Eukaryota_PTN000335994 has function calcium channel activity (GO:0005262) 20150813: Tetrapoda_PTN000336001 has function calcium channel inhibitor activity (GO:0019855) 20150813: Tetrapoda_PTN000336001 has LOST/MODIFIED function uniporter activity (GO:0015292) 20150813: Tetrapoda_PTN000336001 has LOST/MODIFIED function calcium channel activity (GO:0005262) # cellular_component 20150813: Eukaryota_PTN000335994 is found in integral component of mitochondrial inner membrane (GO:0031305) 20150813: Eukaryota_PTN000335994 is found in uniplex complex (GO:1990246) # biological_process 20150813: Eukaryota_PTN000335994 participates in calcium ion transmembrane import into mitochondrion (GO:0036444) 20150813: Eukaryota_PTN000335994 participates in mitochondrial calcium ion homeostasis (GO:0051560) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES MAF: Evidences only for upper node. Due to high degree of duplication, I've propagated almost nothing in other nodes (plants and parasites). # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).