# HISTORY
25 Mar 2016: Updated by: TOUCHUP-v1.15
15 Mar 2016: Updated by: TOUCHUP-v1.14

# molecular_function
20131115: Eumetazoa_PTN000990874 has function deoxyribonuclease activity (GO:0004536) 

# cellular_component
20131115: Eumetazoa_PTN000990874 is found in nuclear chromatin (GO:0000790) 

# biological_process
20131115: Eumetazoa_PTN000990874 participates in apoptotic DNA fragmentation (GO:0006309) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
resolving the relationship between cidea, cideb, cidec, and dffa (syn dff45, icad): dffa negatively regulates dna fragmentation by forming a dimer with dffb (dff40). dffa is cleaved by caspase 3 (pmid:10713148), which releases dffb from the complex. dffb has double-stranded endodeoxyribonuclease activity, thus, dffa negatively regulates the activity of dffb. review 2009 pmid: 18810317. review 2011 pmid:20967381. new go term requested using termgenie: go:1990238 double-stranded endodeoxyribonuclease activity.  when the new term is available, needs to be propagated to the node of the parent of dffb.

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).