# HISTORY 16 Aug 2016: Saved by mfeuerma using Paint 2.22 # molecular_function 20160816: Eukaryota_PTN000306732 has function endopeptidase activity (GO:0004175) # cellular_component 20160816: Eukaryota_PTN000306732 is found in endoplasmic reticulum (GO:0005783) 20160816: Eukaryota_PTN000306732 is found in integral component of plasma membrane (GO:0005887) 20160816: Eukaryota_PTN000306732 is found in gamma-secretase complex (GO:0070765) # biological_process 20160816: Eukaryota_PTN000306732 participates in proteolysis (GO:0006508) 20160816: Bilateria_PTN000306733 participates in Notch receptor processing (GO:0007220) 20160816: Eukaryota_PTN000306732 participates in protein processing (GO:0016485) 20160816: Bilateria_PTN000306733 participates in Notch signaling pathway (GO:0007219) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).