# HISTORY
25 Mar 2016: Updated by: TOUCHUP-v1.15
15 Mar 2016: Updated by: TOUCHUP-v1.14

# molecular_function
20160210: Opisthokonta_PTN000976013 has function histone binding (GO:0042393) 
20160210: Opisthokonta_PTN000976013 has function repressing transcription factor binding (GO:0070491) 
20160210: Opisthokonta_PTN000976013 has function transcription corepressor activity (GO:0003714) 

# cellular_component
20160208: Eukaryota_PTN000293925 is found in Noc2p-Noc3p complex (GO:0030691) 
20160208: Eukaryota_PTN000293925 is found in nucleolus (GO:0005730) 
20160208: Eukaryota_PTN000293925 is found in nucleoplasm (GO:0005654) 
20160208: Eukaryota_PTN000293925 is found in Noc1p-Noc2p complex (GO:0030690) 

# biological_process
20160208: Eukaryota_PTN000293925 participates in ribosomal large subunit biogenesis (GO:0042273) 
20160210: Opisthokonta_PTN000976013 participates in negative regulation of histone acetylation (GO:0035067) 
20160210: Opisthokonta_PTN000976013 participates in negative regulation of transcription from RNA polymerase II promoter (GO:0000122) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
This family is involved in biogenesis of the large ribosomal subunit.
In fungi (e.g. S cerevisiae), it is known as NOC2, while in animals it is known as NOC2L. The A. thaliana gene is referred to as RBL.
In humans, NOC2L has also been called NIR (novel INHAT repressor) because it "can bind to p53 at promoters and inhibit p53-mediated gene transactivation by blocking histone acetylation carried out by p300/CBP" (PMID:24413661). It has also been shown to be involved in ribosome biogenesis in human cells (PMID:22363708).
It seems likely that ribosome biogenesis is the ancestral function since this is very conserved and regulation of transcription is much more easily changeable. As there isn't any other evidence to indicate how far back the transcription role arose, I have looked to the evolutionary scope of p53 (PMID:20516129) to choose how far back to propagate the transcription role of NOC2L.

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).