# HISTORY 07 May 2016: Updated by: TOUCHUP-v1.18 15 Mar 2016: Updated by: TOUCHUP-v1.14 25 Mar 2016: Updated by: TOUCHUP-v1.15 # molecular_function 20150819: root_PTN001759026 has function ATP-dependent DNA helicase activity (GO:0004003) 20150819: root_PTN001759026 contributes to function double-stranded DNA binding (GO:0003690) 20150819: root_PTN001759026 has function damaged DNA binding (GO:0003684) 20150819: node_PTN000288287 has function telomeric DNA binding (GO:0042162) # cellular_component 20150819: root_PTN001759026 is found in Ku70:Ku80 complex (GO:0043564) 20150819: node_PTN000288287 is found in nuclear chromosome, telomeric region (GO:0000784) 20150819: Bacteria _PTN001759079 is NOT found in Ku70:Ku80 complex (GO:0043564) # biological_process 20150819: root_PTN001759026 participates in cellular response to gamma radiation (GO:0071480) 20150819: root_PTN001759026 participates in cellular response to X-ray (GO:0071481) 20150819: root_PTN001759026 participates in double-strand break repair via nonhomologous end joining (GO:0006303) 20150819: root_PTN001759026 participates in DNA duplex unwinding (GO:0032508) 20150819: root_PTN001759026 participates in DNA recombination (GO:0006310) 20150819: node_PTN000288287 participates in telomere maintenance (GO:0000723) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).